ToxStrategies is at SOT 2022

ToxStrategies is excited to be returning to exhibit and present at The Society of Toxicology’s Annual Meeting, March 28th through March 31st.  The meeting is available in person located in San Diego or through virtual attendance for all registered attendees.

Come by and see us at Booth # 934!

Please click on the poster image to view the full abstract and presentation information.

Dr. Amy Mihalchik: Considerations for Standardization and Derivation of Pediatric and Neonatal Tolerable Exposure Limits for Extractable and Leachable Compounds from Medical Devices

Dr. Melissa Heintz: HFPO-DA (GenX) Transcriptomic Responses in Pregnant and Non-pregnant Rat Livers: Analyses to Inform the Role of Maternal Effects on Neonatal Toxicity

Dr. Chad Thompson: Use of Targeted Mode-of-Action Research to Inform Human Health Risk Assessment of Hexavalent Chromium

Dr. John Rogers: Development of a Putative Adverse Outcome Pathway for Neonatal Mortality in Rodents: Implications for Human Health Risk Assessments of PFAS

Dr. William Klaren: Reproduction and Developmental Toxicological Evaluation of Piperonyl Butoxide (PBO)

Ms. Deborah Proctor: Refined Health Risk Assessment for Residential Exposures to Manganese in EAF Steel Slag

Ms. Seneca Fitch: Comparison of Public and Private Literature Databases for Toxicological Investigations

 

Workshops and Sessions:

  • SPC Highlights Emerging Scientists: Nanotoxicology, Dr. Daniele Wikoff, Co-Chair Tuesday, March 29th, 1:00pm CC Room 8
  • Safer Chemical Tools and Practices: Successes in Advancing Safer Chemical Selection on a Global Scale: Panel Discussion/Q&A, Lauren Brown, Co-Chair Wednesday, March 30th, 11:00am CC Ballroom 6B
  • Bridging the Past, Present, and Future of Study Quality Evaluations in Toxciology: A Summary of Recommendations to Researchers for the Conduct and Reporting of Toxicological Studies, Dr. Daniele Wikoff, Presenter Thursday, March 31st, 10:45am CC Ballroom 6E
  • How Does Your Study Measure up? The Evolution of Study Quality Evaluations in Toxicology and Risk Assessment, Dr. Daniele Wikoff, Co-Chair Thursday, March 31st, 8:30am CC Ballroom 6E
  • Mode of Action, Adverse Outcome Pathways, and Key Characteristics (KCs): Proposed Steps Forward and Mid-Course Corrections, Dr. Daniele Wikoff, Chair Tuesday, March 29th, 8:00am CC Ballroom 6D
  • Picking the Right Tool: Using Evidence-Based Toxicology to Evaluate Mechanistic Data in KC, AOP, and MoA Constructs, Drs. Daniele Wikoff, Grace Chappell, and Susan Borghoff, Presenters Tuesday, March 29th, 9:50am CC Ballroom 6D
  • Computational I Poster Session, Dr. Grace Chappell, Chair
  • DNA Damage and Repair Poster Session, Lauren Brown, Chair
  • Emerging Technologies Poster Session, Dr. William Klaren, Chair

 

For a complete agenda of sessions and presentations click here.

 

Laurie Haws is SOT Vice President-Elect

ToxStrategies congratulates our President and co-founder Dr. Laurie Haws on being elected Vice President-Elect of the Society of Toxicology (SOT)! Dr. Haws and the full slate of newly elected officers and committee members will begin their terms on May 1st. SOT, founded in 1961, is a professional and scholarly organization of scientists from academic institutions, government, and industry, representing the great variety of scientists who practice toxicology in the US and abroad. Dr. Haws is passionate about the Society’s mission to create a safer and healthier world by advancing the science and increasing the impact of toxicology. She is a graduate of the Curriculum in Toxicology at the University of North Carolina at Chapel Hill, a Diplomate of the American Board of Toxicology (DABT), and a Fellow of the Academy of Toxicological Sciences (ATS). Dr. Haws has more than 30 years of experience in the areas of toxicology, human health risk assessment, risk communication, and scientific and regulatory policy.

 

ToxStrategies continues to be active in the Society of Toxicology

 

ToxStrategies is pleased to announce that the following scientists are running for leadership positions in the Society of Toxicology (SOT):

  • Laurie Haws – Vice President, SOT Council
  • Lauren Brown – Vice President for the Sustainable Chemicals Through Contemporary Toxicology Specialty Section
  • William Klaren – Secretary/Treasurer for In Vitro and Alternative Methods (IVAM) Specialty Section and Junior Counselor for Regulatory and Safety Evaluation Specialty Section (RSESS)
  • Rayetta Henderson – Councilor for Food Safety Specialty Section
  • Allison Franzen – Junior Councilor for Food Specialty Section and Junior Councilor Mixtures Specialty Section
  • Jon Urban – Treasurer for the Carcinogenesis Specialty Section

Ballots are due by Feb 1, 2022.  We wish them all good luck in the upcoming elections!

 

ToxStrategies Responds to Growing Need to Assess Exposures and Risks of PFAS in Containers and Packaging

An emerging class of chemicals of great interest is PFAS, short for per- and polyfluoroalkyl substances.  PFAS have been used for decades in packaging and textiles to help repel water, oil/grease, and stains. Recently, reports have emerged indicating that PFAS may migrate from containers at low levels into the product being contained. This, along with the apparent widespread use of PFAS, has resulted in growing concern about the possible public health risks associated with using products from packages or containers that may contain measurable PFAS. These concerns are magnified by reports that some PFAS has been detected in humans and the increasingly low regulatory limits, (i.e., parts per trillion) that have been proposed to date.

ToxStrategies has supported a variety of clients in assessing exposure and risk from PFAS, including those associated with containers and packaging. Through this work, our scientists have developed expertise in PFAS toxicology, test plan preparation, and critical evaluation of data related to migration of PFAS from packages and containers into products.  We have assessed the potential for health risk from exposure to PFAS based on a wide variety of conditions of use in industrial, commercial and residential products and used available biomonitoring and biological fate data to inform perspective and understand trends. We are also knowledgeable about federal, state, and European Union PFAS regulations and standards; laboratory methods for analyzing PFAS migration in various matrices; and PFAS environmental fate and transport processes.

Summary of Toxicology Forum workshop on assessing chemical carcinogenicity

A new publication presents an overview of a Toxicology Forum virtual workshop held in December 2021, titled, “Assessing [chemical] carcinogenicity: Hazard identification, classification, and risk assessment.” This state-of-the-science workshop looked at the issue of re-examining long-standing test methods and risk assessment approaches based on new understandings. With the US EPA currently updating its guidelines (including the 2005 Guidelines for Carcinogen Risk Assessment), the workshop allowed national and international experts and stakeholders to exchange information and ideas regarding revisions to these guidance documents, looking toward the next steps in modernizing the techniques of carcinogenicity identification and risk assessment.

In the open-access article in Critical Reviews in Toxicology the authors acknowledge that no single new approach method (NAM) is likely to replace the widely used rodent chronic bioassay, and therefore, “activities to combine NAMs into integrated approaches for testing and assessment, or preferably into defined approaches… that include data interpretation procedures, were identified as urgent research needs.”

Dr. Chad Thompson presented a case study involving hexavalent chromium during the panel discussion on mode of action. In addition, ToxStrategies Managing Principal Scientist Dr. Laurie Haws currently serves as Vice President of the Toxicology Forum and will move into the role of president during 2022.

ToxStrategies congratulates Laurie Haws on ATS Fellowship

ToxStrategies is pleased to announce that Managing Principal Scientist Dr. Laurie Haws has been accepted as a Fellow of the Academy of Toxicological Sciences (ATS).  This honor represents a significant milestone in the development of Dr. Haws’ career in toxicology. To be recognized as a Fellow by the Academy, one must have an exemplary record of professional accomplishment, as well as extensive evidence of recognition by peers of competency and sound scientific judgment in toxicology, as reflected by appointment or election to councils, committees, etc. Dr. Haws has more than 30 years of experience in the fields of toxicology, human health risk assessment, and safety assessment and is a co-founder of ToxStrategies, Inc. Please join us in congratulating Dr. Haws on this accomplishment.

Paper discusses role of exposure monitoring to support environmental justice

ToxStrategies scientists Drs. LeeAnn Racz and Bill Rish have published a Brief Communication titled, “Exposure monitoring toward environmental justice,” in the journal Integrated Environmental Assessment and Management. The paper discusses the need (in light of a Biden Administration Executive Order) to enhance risk assessment methods and exposure monitoring techniques to more explicitly address issues of environmental justice, such as the interaction between chemical exposures and nonchemical stressors, that can affect individual communities, even down to the neighborhood level. The authors suggest using enhanced monitoring with personal and portable sensors and deploying internet-linked sensors, as well as forming community partnerships and thoughtfully managing big data to inform community decision making. In addition to being published in the journal, Dr. Racz will present this work at the North America annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC), to be held virtually November 14–18, 2021.

 

EPA’s Pending Reporting Requirements for PFAS

EPA has proposed a rule requiring companies to report their use of PFAS, which will affect a vast number of entities. As proposed, the rule requires businesses that import, process, or manufacture PFAS to detail these uses for the past 10 years (back to 2011). Information to be reported includes chemical identity, environmental and health effects, volumes processed and manufactured, worker exposure, categories of use, disposal, and by-products. No exceptions are expected to be allowed for small businesses, or for by-products, impurities, or substances formed during product use or aging. The comprehensive reporting requirement could be particularly burdensome to entities that have not previously been required to document or report usage of various substances. The rule was proposed in June 2021, with the public commenting period ending in September. The final rule is anticipated soon.

 

ToxStrategies has extensive expertise in assessing PFAS environmental and human health exposures, hazards, and effects. We are ready to partner with you in navigating this new and far-reaching rule.