Publications

Blanchette AD, Burnett SD, Rusyn I, Chiu WA. 2022. A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability. J Pharmacol Toxicol Methods (In press).

Luo YS, Chen Z, Blanchette AD, Zhou YH, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC) cardiomyocytes. Food Chem Toxicol 149, doi: 10.1016/j.fct.2021.111979. PMID: 33450301.

Blanchett A, Burnett SD, Grimm FA, Rusyn I, Chiu WA. A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model. Society of Toxicology, meeting session, “Closing the Data Gap: Assessing Population Variability using Next Generation Tools in Toxicology,” March 2021.

Burnett SD, Blanchette AD, Chiu WA, Rusyn I. 2021. Cardiotoxicity hazard and risk characterization of ToxCast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors. Chem Res Toxicol.

Blanchett A, Burnett SD, Grimm FA, Rusyn I, Chiu WA. A Bayesian new approach method for human population-wide risk characterization of cardiotoxicity. Presentation to Texas A&M University Toxicology Seminar Series, November 2020.

Blanchette A. Bioiformatic tools for research. Presented during annual Toxicology Bootcamp, February 2020 and April 2021.

Blanchette AD, Burnett SD, Grimm FA, Rusyn I, Chiu WA. 2020. A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model. Toxicol Sci 178(2):391–403, doi: 10.1093/toxsci/kfaa151. PMID: 33078833.

Blanchett A, Burnett SD, Grimm FA, Rusyn I, Chiu WA. An in vitro-in silico model for characterizing hazard and population variability in cardiotoxicity induced by environmental chemicals. Poster presentation at the Lone Star Society of Toxicology annual meeting and the Texas A&M Annual CVM Trainee Symposium; oral presentation at the Texas A&M Toxicology Seminar Series and the 2020 SOT Annual Meeting, Texas Edition virtual meeting, 2020

Blanchette A., Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Rusyn I, Chiu WA. Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc. Poster presentation at the 2018 Texas A&M Toxicology Symposium; oral presentation at Lone Star Society of Toxicology 2018 conference; poster presentation at SOT, 2018–2019.

Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Rusyn I, Chiu WA. 2019. Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration‐QTc relationships. Clin Pharmacol Therapeut 105(5):1175–1186, doi: 10.1002/cpt.1259. PMID: 30346629.

Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711, doi: 10.1016/j.taap.2019.114711. PMID: 31425687.

Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh N-H, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. 2018. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 35(4):441–452, Epub 2018/07/08, doi: 10.14573/altex.1805301. PMID: 29999168.

Blanchett A, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Rusyn I, Chiu WA. An in vitro human Bayesian population pharmacodynamic model for predicting effects on heart rhythm. Presented at EPA Organotypic Culture Models STAR center update meeting, May 2018