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ToxStrategies scientists publish novel systematic review on potential adverse health effects associated with caffeine consumption

ToxStrategies scientists, along with a team of multidisciplinary experts, published a novel systematic review on the potential adverse health effects associated with caffeine consumption in healthy adults, pregnant women, adolescents, and children. This comprehensive assessment included evaluation of cardiovascular, behavioral, reproductive & developmental, bone & calcium, and acute effects. When the total body of evidence was evaluated, and when study quality, consistency, level of adversity, and magnitude of response were considered, the evidence generally supported that consumption of up to 400 mg caffeine/day in healthy adults is not associated with overt adverse effects. Evidence also supported consumption of up to 300 mg caffeine/day in healthy pregnant women as an intake that is generally not associated with adverse reproductive and developmental effects. Limited data were identified for child and adolescent populations; the available evidence suggested that 2.5 mg caffeine/kg body weight/day remain acceptable. Click here to read one of first reviews to apply systematic review methodologies to toxicological assessments.