Per-and Polyfluoralkyl Substances (PFAS)

Concerns about potential health risks associated with low-level exposures to PFAS, along with their widespread uses and reported detections in various environmental media and products, are triggering regulation, litigation, and an urgent need to apply the best available science in evaluating the exposure, toxicology, and epidemiology to characterize potential human health risks. ToxStrategies has scientific expertise and advanced technical resources to assist clients in navigating the scientific environment and growing regulatory labyrinth associated with PFAS.

ToxStrategies’ and EpidStrategies’ capabilities and experience include (but are not limited to) protocol development for PFAS extraction and migration from products, articles, and containers; assessment of fate and transport of PFAS; exposure and risk assessment of PFAS in environmental media; exposure and safety assessment of PFAS contained in wide variety of products, including foods, packaging, personal care products, cosmetics, health and beauty care products, and commercial/industrial products; in-depth PFAS toxicology knowledge; development of PFAS toxicity criteria and toxicokinetic modeling; critical assessment and systematic reviews of PFAS epidemiological studies and evidence to understand impact on health outcomes; and critical evaluation and systematic reviews of PFAS literature.

PFAS Source Identification

  • Conditions of Use
  • Source forensics
  • Ambient PFAS data summaries

PFAS Chemistry and Analysis Support

  • Sampling and Analysis Plans
  • Product extraction and migration testing protocols
  • Data Validation
  • Statistical analysis of data

PFAS Transport and Fate Assessment

  • Studies of PFAS migration from materials
  • Environmental transport, transformation, and loss modeling
  • Atmospheric dispersion and deposition modeling
  • Plant and animal uptake, bioaccumulation, and bioconcentration

PFAS Exposure and Risk Assessment

  • Knowledge of background (ambient) PFAS exposures and biomonitoring data
  • Characterization of soil, groundwater, surface water, and air exposures and human health risks
  • Safety assessments of PFAS in consumer products, health and beauty care products, and foods
  • Concentrations in articles of commerce

PFAS Toxicology and Toxicokinetics

  • State-of-the-art knowledge of PFAS toxicity
  • Development of PFAS toxicity criteria
  • Threshold of Toxicological Concern (TTC) applications, QSAR and read-across studies, development toxicity studies, transcriptomic analysis, mode-of-action studies, PFAS low exposure risk thresholds, evaluation of PFAS endocrine activity
  • Physiologically Based Pharmacokinetic (PBPK) models
  • Comprehensive literature reviews, Systematic Reviews (SRs), and risk-of-bias (RoB) analyses of the PFAS evidence base

PFAS Regulatory Support

  • In-depth knowledge of state, federal, and international PFAS screening levels and their scientific basis
  • Development of cleanup levels under state rules
  • Prioritization of PFAS compounds
  • TSCA Pre-manufacture Notice (PMN) preparation and toxicity testing
  • Preparation of existing chemical risk evaluations under TSCA

PFAS Epidemiology

  • Evidence-based assessment of PFAS based on evaluation of epidemiological studies
  • Epidemiological studies of community cohorts potentially exposed to PFAS
  • Critical evaluation of epidemiological literature on PFAS exposure and health outcomes using systematic literature review methods and risk-of-bias assessments