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ToxStrategies’ Scientists Publish Acute/Short-term Inhalation Guideline for Manganese Supported by PBPK Modeling



ToxStrategies’ scientists Camarie Perry, Stephanie Vivanco, Ann Holbrow Verwiel, and Deborah Proctor conducted a regulatory and scientific literature review to develop an acute/short-term inhalation guideline for manganese in ambient air, protective of respiratory effects and neurotoxicity. To reduce uncertainty regarding manganese accumulation in the brain from short-term exposures, the authors used previously published physiologically-based pharmacokinetic (PBPK) modelling to support that the derived 24-h inhalation guideline of 5 μg/m3 is protective for sensitive life-stages. As very few short-term exposure guidelines have been established, this guideline provides new information for use in air toxics risk assessment.

Use of physiologically based pharmacokinetic modeling to support development of an acute (24-hour) health-based inhalation guideline for manganese – ScienceDirect