ToxStrategies is a multidisciplinary scientific consulting firm that strives to develop innovative solutions to address the scientific, technical, and regulatory challenges confronting our clients. We have a reputation for applying sound science in all that we do, for leading-edge thinking, and for tailoring our approach to meet the specific needs of our clients, whether a rapid response or a comprehensive analysis is needed.
Potential human health risks associated with pesticides and related chemicals are a growing concern, and ToxStrategies offers deep expertise in the scientific disciplines needed to address these issues. Our team has extensive experience in pesticide toxicology and food safety, including evaluating risks from insecticides, herbicides, disinfectants, sanitizers, fumigants, biocides, fungicides, repellents, surfactants, and other adjuvants. We assess exposures that may occur through agricultural uses such as crop application or drift, residential and consumer activities such as use of bug repellents and weed killers, and food consumption. Our scientists bring broad experience with a wide range of active ingredients, have published numerous risk assessments in the scientific literature, and are frequently invited to contribute to pesticide-related scientific review and advisory committees.
Specific relevant areas of expertise include the following:
Regulatory and Registration Support
- Compile and review existing/generated toxicity data to support registration effort
- Gap assessment for toxicity data
- Study design/placement/monitoring
- Evaluation of GHS and international classification standards
Human Health Risk Assessment Support
- Systematic review of literature
- Searching, critical appraisal, and synthesis of literature
- Weight of evidence evaluation of available information
- Mode of action assessment of toxic outcomes
- Toxicokinetics and PBPK modeling
- Exposure assessment and dose estimation
Ecotoxicology and Environmental Risk Assessment Support
- Evaluation of ecotoxicological data
- Ecological risk assessment
- Gap assessments for ecological toxicity data
- EPA’s ECOTOX software
Relevant Software Expertise
- USEPA’s Incident Data System (IDS)
- International Pesticide Information (e.g., EU’s Pesticides Database; FAO/WHO, and others)
- AGRITOX
- Benchmark Dose Modeling (BDM)
- EPI Suite
- IVIVE (in vitro-to-in vivo extrapolation) modeling
- Inhalation dosimetry (e.g., MPPD)
- ConsExpo Web