Professional Profile
Ms. Melissa Vincent is a Supervising Scientist in ToxStrategies’ Health Sciences Practice. She has 15 years of applied experience in human health risk assessment and has demonstrated proficiency in the use and application of epidemiology, toxicology, and biostatistics in support of evidence integration and quantitative dose-response assessments. Ms. Vincent has expertise in statistical analysis of epidemiological and toxicological data, and determination of exposure risk and dose-response relationships for both cancer and noncancer outcomes. This includes evaluation of pesticides, food flavorings, disinfection products, arsenic, and metals (including nickel, hexavalent chromium, and cobalt). Ms. Vincent applies benchmark dose and meta-regression analysis to derive points of departure, including effective concentrations. These analyses frequently are based on epidemiological information and are conducted with consideration of mode of action in support of model determination. In her practice, Ms. Vincent has developed risk assessment frameworks for critically evaluating epidemiological evidence for integration with toxicological hazard information and for use in quantitative risk assessments. These frameworks include use of risk-of-bias assessments and systematic study quality evaluations. Ms. Vincent also collaborated with biomathematicians in evaluating a variety of data sets for consistency with, or violation of, dose addition, work that earned an Honorable Mention for the US Environmental Protection Agency’s Scientific and Technical Achievement Award.