ToxStrategies consulting scientists have unique and extensive experience in the fields of neurotoxicology, neuropharmacology, and neuroscience. With our diverse experience, we can help design pre-clinical neurotoxicology protocols and oversee in vivo studies. Furthermore, our experts can aid with the interpretation of pre-clinical neurological data and help characterize the potential neurotoxicity of a drug.
Selected examples of ToxStrategies’ consulting services include:
Electrophysiology and in vitro assays
- GPCR binding
- Protein expression
- Neuronal cell function (e.g., dopaminergic, cAMP, MAPK, arachidonic acid pathways)
- Whole-cell and patch-clamp electrophysiology
- Single-channel electrophysiology
Neuropharmacology
- Allosteric modulation of ionotropic receptors
- Activation and alteration of dopaminergic systems by drugs of abuse (e.g., cocaine and alcohol)
- Behavioral studies (e.g., rewarding and reinforcing effects of drugs; effects of drugs on learning and memory)
Neurotoxicology and CNS Safety Pharmacology
- CNS safety pharmacology (rats and nonhuman primates)
- Juvenile toxicology studies with neurobehavioral endpoints
- In vivo neurotoxicology study design
- Advise on CNS histopathology and special immunohistochemical staining (e.g., GFAP, Iba-1, silver staining)
Specific Diseases
- Drug addiction
- Alzheimer’s disease
- Parkinson’s disease
- Multiple sclerosis
- Schizophrenia
- Rare neurological disorders
Neurotoxicity Associated with Environmental Exposures
- Heavy metals (e.g., manganese)
- Pesticides (e.g., pyrethroids, organophosphates)
- Polychlorinated biphenyls (PCBs)
For more information about ToxStrategies’ consulting services, please contact us.