The Joint Research Centre (JRC) recently published a technical report reviewing recent developments in mixtures assessment methodologies and their applications in the hazard assessments.
The report reviews the use of emerging technologies, including in vitro assays, omics approaches, SAR and QSAR modeling, read-across, and PBTK modeling in evaluating mixtures toxicity. Survey results are also included detailing how experts use these novel methodologies to evaluate chemical mixtures. The report concludes that there is high potential for the application of these new methodologies; however, more guidance and standardization on the use of these tools in hazard assessment of mixtures is still needed.
For a copy of the JRC’s technical report on scientific methodologies for the assessment of combined effects of chemicals – a survey and literature review, please click here.