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Recent publication on assessment of mechanistic data for synthetic food dyes and neurobehavioral signals



A recently published article by ToxStrategies scientists Dr. Grace Chappell, Dr. Susan Borghoff, and Dr. Janice Britt presents the evaluation of mechanistic data in an assessment of potential neurobehavioral effects for the seven synthetic colors that are approved for use in food by the US FDA. The assessment was specific to in vitro and other new approach methods (NAMs). A systematic identification of molecular events potentially related to neuro-relevant processes and outcomes was conducted to enable mapping of high-throughput screening (HTS) assays from the ToxCast/Tox21 database to such molecular events and/or related genes. Based on the mapping, neuro-relevant HTS data for seven FDA-approved synthetic food colors were evaluated, as well as neuro-relevant NAMs data for the colors identified in published literature. The findings support an overall lack of neuro-related activity associated with the seven food colors, with the exception of neurotransmitter signaling by erythrosine. The open-access article was published in Food and Chemical Toxicology.