ToxStrategies scientists published a GLP OECD designed reproductive toxicity study (Thompson et al., 2020) assessing the potential for adverse follicular effects in mice following exposure to hexavalent chromium [Cr(VI)] in drinking water. This study demonstrated that reproductive toxicity was limited to extremely high doses that are not environmentally-relevant. At Cr(VI) doses consistent with, and substantially higher than, the basis for the California Proposition 65 Maximum Allowable Dose Level (MADL), no effects are observed, supporting that the MADL should be re-evaluated.
Thompson CM, Donahue DA, Hobbs C, Costecalde Y, Franzen A, Suh M, Proctor DM, Harris MA. 2020. Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice. Regul Toxicol Pharmacol 116, open access: