Professional Profile
Dr. Jacob Reynolds is a toxicologist in ToxStrategies’ health sciences practice. He received his Ph.D. in Biomedical Engineering and Environmental and Integrated Toxicological Sciences from Michigan State University. His dissertation focused on applying new approach methods (NAMs) to study the etiology of structural birth defects, specifically orofacial clefting. Dr. Reynolds has experience with in vitro microphysiological model development, applying computer numerical control machining to create custom, microplate-based systems. Using this technique, he has worked extensively with a microphysiological model of orofacial development designed to capture the epithelial-mesenchyme interface, and has applied it to study disruption of the Sonic Hedgehog (SHH) signaling pathway. He has conducted several systematic literature reviews and has worked with the Organisation for Economic Co-operation and Development (OECD) adverse outcome pathway (AOP) development program to create and publish AOPs. He has experience using statistical analysis software, including R and GraphPad Prism, to analyze and visualize data.
Dr. Reynolds has presented his research at national and international scientific meetings and has reported his results in peer-reviewed scientific journals.