Professional Profile
Dr. Allison Franzen has eight years of experience in human health risk assessment. Her areas of expertise include quantitative risk assessments, evidence integration, weight-of-evidence analysis, systematic reviews, hazard identification, toxicological and pharmacokinetic critical literature review and searching, physiologically based pharmacokinetic (PBPK) modeling, PBPK USEPA quality assurance project plan (QAPP) documentation, benchmark dose modeling, and exposure assessments. Dr. Franzen has performed large-scale toxicity systematic reviews and smaller literature reviews and assessments for numerous chemicals. She has performed multiple dose-response analyses using USEPA’s noncancer and cancer methods, and she has worked with biologically based interaction models to understand the interactions of the chemical mixture and its potential impact, with an exposure analysis of potential health effects.
Dr. Franzen has conducted literature reviews to determine the most appropriate biomarkers of exposure and effect for multiple chemicals. She has expanded and created multiple PBPK models and has recently been working to convert models from the now-outdated ACSLX language to R. She has developed an adverse-outcome pathway (AOP) and applied AOPs to inform the mechanism of toxicity for chemicals. Dr. Franzen is currently working on a chemical assessment under the new Toxic Substances Control Act (TSCA) guidelines.