A recently published article by ToxStrategies scientists, with Dr. Daniele Wikoff as lead author, presents the systematic identification, appraisal, and integration of mechanistic data in an assessment of potential carcinogenicity of the non-nutritive sweetener aspartame. Based on the evaluation of over 1300 measurements/assay endpoints related to one or more key characteristics of carcinogens (KCC) reported in the literature and via high-throughput screening data, the authors found a lack of evidence for activity across the mechanistic database. These results align with the overall lack of tumor response to aspartame in rodent cancer bioassays, corroborating previous reports of a lack of carcinogenicity related to aspartame exposure. The open access article can be found here: https://www.sciencedirect.com/science/article/pii/S0278691519306568