Causation Analysis

ToxStrategies and EpidStrategies scientists have decades of consulting and research experience in evaluating the causal relationships between disease occurrence and exposure to chemicals in consumer products, the workplace, and the environment.  Our team of experts has provided testimony in US state and federal court, mediation, and international arbitration, and has experience addressing high profile matters involving personal injury, toxic tort, class certification, and product liability.

Services

  • Evidence-based toxicology
  • Design and conduct of exposure simulation studies
  • Exposure reconstruction from measured or modeled data
  • Derivation of health-based chemical exposure thresholds
  • Benchmarking reconstructed exposures vs exposure thresholds
  • Epidemiologic study design, implementation, and interpretation
  • Meta analyses of epidemiologic studies
  • Assessment of epidemiologic studies using accepted criteria (e.g., Bradford-Hill)

Example Areas of Expertise

  • Talcum powder exposure
  • PFAS exposure via tap water consumption
  • Medical devices and pharmaceuticals
  • Childhood lead exposures via tap water, soil, dust, and dietary consumption
  • Occupational exposure to flavoring compounds (e.g., diacetyl, 2,3-pentanedione)
  • Solvent exposures (e.g., TCE, PCE, 1,4-dioxane)
  • Community PCB exposures