Rapid Exposure Estimation

Rapid exposure estimation is the use of novel approaches and strategies to quickly estimate exposures. Scientists providing ToxStrategies’ consulting services utilize rapid exposure estimation to efficiently estimate human and environmental exposures across a wide range of chemicals, pathways, and receptors. Rapid exposure estimation offers time and cost-efficient strategies to inform decision making during chemical regulatory assessments, product development, and screening assessments. Many models utilize high-throughput techniques, where multiple exposure scenarios can be estimated at once with minimal inputs, which allows for a quick turnaround in the chemical prioritization process. Our scientists are also skilled in multiple statistical frameworks to evaluate results such as bayesian and probabilistic statistics.

Exposure estimation

  • Residential, consumer products, occupational, dietary exposures, far-field exposures (industrial and pesticides). Examples of models used:
  • ChemSTEER 
  • ConsExpo 
  •  Consumer Exposure Model (CEM) 
  • ECETOC TRA 
  • Advanced REACH tool (ART) 
  • IHMOD/IHSKINPERM 
  • NHANES/FNDDS 
  • Indoor Air Quality and Inhalation Exposure (IAQX) 
  • AERMOD 
  • Structured Deterministic Model (SDM) 2.0 

Exposure forecasting

  • EPA’s Systematic Empirical Evaluation of Models (SEEM) framework
  • ECETOC Targeted Risk Assessment (TRA) tool
  • EPA’s ExpoCast framework

Data Analysis

  • Bayesian frameworks
  • Probabilistic risk assessments

Chemical use information

  • EPA’s CPDat (functional use, weight fraction, etc.)
  • ECHA’s Information on Chemicals
  • OECD eChem Portal

Rapid risk evaluations

  • High-throughput risk-based chemical prioritization
  • High-throughput margin of exposure (MoE) and activity exposure ratio (AER)
  • In vitro-to-in vivo extrapolation to relate in vitro measures of bioactivity to in vivo exposures

Non-targeted analyses

  • Study design and data acquisition (LCMS, BP4NTA)
  • Data interpretation and prioritization (HCD, AMOS)
  • Chemical mixtures in environmental samples

Physical chemical property and environmental fate prediction

  • EPISuite
  • OPERA
  • VEGA