Rapid Exposure Estimation

Exposure estimation

Residential, consumer products, occupational, dietary exposures, far-field exposures (industrial and pesticides). Examples of models used:

  • ChemSTEER
  • ConsExpo
  • Consumer Exposure Model (CEM)
  • ECETOC TRA
  • IHMOD/IHSKINPERM
  • NHANES/FNDDS

Exposure forecasting

  • EPA’s Systematic Empirical Evaluation of Models (SEEM) framework
  • ECETOC Targeted Risk Assessment (TRA) tool
  • EPA’s ExpoCast framework

Tailored exposure assessments

  • Bayesian frameworks
  • Probabilistic risk assessments

Chemical use information

  • EPA’s CPDat (functional use, weight fraction, etc.)
  • ECHA’s Information on Chemicals
  • OECD eChem Portal

Rapid risk evaluations

  • High-throughput risk-based chemical prioritization
  • High-throughput margin of exposure (MoE) and activity exposure ratio (AER)
  • In vitro-to-in vivo extrapolation to relate in vitro measures of bioactivity to in vivo exposures

Non-targeted analyses

  • Chemical mixtures in environmental samples

Physical chemical property and environmental fate prediction

  • EPISuite
  • OPERA
  • VEGA