A recently published article by ToxStrategies scientists and others presents the systematic identification, appraisal, and integration of mechanistic data in an assessment of potential carcinogenicity of the non-nutritive sweetener sucralose. Based on the evaluation of over 700 measurements/assay endpoints related to one or more key characteristics of carcinogens (KCC) reported in the literature and via high-throughput screening data, the authors found a lack of evidence for activity across the mechanistic database. These results align with the overall lack of tumor response to sucralose in rodent cancer bioassays, corroborating previous reports of a lack of carcinogenicity related to sucralose exposure. The open-access article can be found here: https://www.sciencedirect.com/science/article/pii/S027869151930688X.