EpidStrategies’ scientists Mina Suh, Naimisha Movva, and Sue Pastula have authored a new systematic literature review in Cancer Treatment and Research Communications. This review summarizes the prevalence of MTAP deletions or loss of expression and accompanying prognostic impacts in adult and pediatric patients with specific solid or hematologic cancers. This systematic literature review is the first to comprehensively describe and summarize current MTAP evidence across several solid and hematologic cancers. High prevalence of MTAP homozygous deletions or loss of protein expression are noted in patients. Given its role in inhibiting PRMT5, a critical tumor component, MTAP may be a promising target for cancer therapy.
Please contact Mina Suh (msuh@epidstrategies.com) for additional information.