Professional Profile
Dr. Amanda Buerger is a toxicologist in ToxStrategies’ Health Sciences practice with experience in human health risk assessment, with a focus on applying weight-of-evidence (WoE) approaches and mode-of-action (MoA) analyses. She has provided support to a range of clients, including pharmaceutical companies, chemical manufacturers, universities, and consumer product producers. She studies the health effects related to exposure to a wide range of chemicals, including environmental contaminants like pesticides, phthalates, industrial chemicals and ingredients used in consumer products like flavorants.
Dr. Buerger conducts risk assessments that apply WoE approaches incorporating clinical, nonclinical, in vivo, in vitro, and in silico data. She leverages dose-response modeling and new approach methodologies (NAMs) in her projects, including using ‘omics data, to inform MoA and reference value derivation. She is experienced in conducting statistical analyses using R (RStudio) and benchmark dose modeling. She conducts systematic reviews and evidence mapping by leveraging software such as DistillerSR and SysRev to evaluate the potential for agents to act as human carcinogens or metabolism or endocrine function disruptors.
Dr. Buerger has produced and contributed to a variety of work products for clients, including: U.S. EPA submissions; occupational exposure limit (OEL), occupational exposure banding (OEB), permissible daily exposure (PDE), and allowable daily exposure (ADE) derivation documents; MoA analyses; and inhalation risk assessment courses. Dr. Buerger also has experience providing litigation support related to pesticides, chlorine, asbestos, talc, and food flavorings.