Publications

Buerger AN, Heintz MM, Haws LC, Thompson CM. 2026. Mode-of-action and human relevance assessment for diisononyl phthalate-induced liver tumors in rodents. J Appl Toxicol; doi: 10.1002/jat.70223. Online ahead of print May 5th. PMID: 42086044. 

Lea IA, Buerger AN, Vincent MJ,…, Choksi NY, Schaefer H, Britt J, Fitch S, Haws L, Borghoff SJ. 2026. Evaluating the potential carcinogenic hazard of diisononyl phthalate in humans via systematic integration of human, animal cancer studies, and mechanistic data. Curr Res Toxicol 10(Apr 30):100295; doi: 10.1016/j.crtox.2026.100295.

Buerger AN, Thompson CM, Heintz MM, Maberti S, Palermo CM, Haws LC. 2026. Application of quantitative and qualitative uncertainty assessment risk management decision-making: A case study with diisononyl phthalate. Food Chem Toxicol 116110; doi: 10.1016/j.fct.2026116110. Online ahead of print April 25. PMID: 42035978.

Buerger AN, Vincent MJ, Fitch S, Rivera B, Engel N, Zhang J, Rushton EK, Borghoff SJ. 2026. A mechanistic evaluation of the metabolism disrupting potential of methyl tert-butyl ether. Curr Res Toxicol 10(Apr 20):100290; doi: 10.1016/j.crtox.2026.100290. PMID: 42057916.

Massarsky A, Evans VJB, Fung ES, Yang LGL, Rogers KL, Buerger AN, Maier A, Reichard JF. A framework for assessing the safety of degraded pharmaceuticals for long-duration space missions—Part II: Framework application in four case studies. Crit Rev Toxicol; doi: 10.1080/10408444.2026.2633422. Online ahead of print April 16. PMID: 41988975.

Massarsky A, Evans VJB, Fung ES, Yang LGL, Rogers KL, Buerger AN, Maier A, Reichard JF. A framework for assessing the safety of degraded pharmaceuticals that will be required for long-duration space missions—Part I: Framework development. Crit Rev Toxicol; doi: 10.1080/10408444.2025.2533943. Online ahead of print April 9. PMID: 4195218.

Buerger AN, Heintz MM, Haws LC, Nyambego H, Palermo CM, Thompson CM. Mode of action and human relevance assessment for diisononyl phthalate (DINP)-induced liver tumors in rodents. Abstract 3324, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Buerger AN, Lea IA, Vincent MJ,…, Choksi NY, Britt J, Fitch S, Rogers S, Schaefer H, Haws L,…, Wikoff D, Borghoff SJ. Systematic evaluation of the carcinogenic potential of di-isononyl phthalate in humans. Abstract 3314, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Heintz MM, Buerger AN, Haws LC, Cullen JM, East AW, Thompson CM. 2025. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Pparα-null mouse livers. Toxicol Sci 206(1):183-201; doi: 10.1093/toxsci/kfaf049. PMID: 40216583.

Heintz MM, Buerger AN, Haws LC, East AW, Cullen JM, Thompson CM. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mice. Abstract 3972, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025

Fitch S, Wikoff D, Foreman J, Buerger A, Haws L, Palmero C. Assessment of relative potency factors for six phthalates. Abstract 4235, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Buerger AN, Vincent MJ, Fitch S, Rushton EK, Borghoff SJ. Evaluation of potential obesogenicity through a mode of action approach: A case study with MTBE. Abstract 3928, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera BN, Fitch S, Buerger A, Choksi N, Franzen A, Bus J, Rushton EK, Lea I. Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data. Abstract 4702, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Massarsky A, Buerger AN, O’Neill HC, Gaffner J, Mucs D, Baskerville-Abraham I, Maier A. Derivation of Maximum Acceptable Group Levels (MAGLs) for ionones and related compounds. Abstract 4764, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA. 2025. Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224. PMID: 40084233.

Rogers JM, Buerger AN, Heintz MM, Palermo CM, Haws LC, Lea IA. 2025. Evaluation of a hypothesized Sertoli cell-based adverse outcome pathway for effects of diisononyl phthalate on the developing testis. Curr Res Toxicol 8:100219; doi: 10.1016/j.crtox.2025.100219. PMID: 40123861.

Lea IA, Buerger AN, Feifarek D, Mihalchik A, Heintz MM, Haws LC, Nyambego H, Goyak K, Palermo C, Borghoff SJ. 2025. Evaluation of the endocrine disrupting potential of Di-isononyl phthalate. Curr Res Toxicol 8:100220; doi: 10.1016/j.crtox.2025.100220. PMID: 40092461. Corrigendum 8:100233; doi: 10.1016/j.crtox.2025.100233; PMID 40529321.

Bates CA, Vincent MJ, Buerger AN, Santamaria AB, Maier A, Jack M. 2024. Investigating the relationship between β-carotene intake from diet and supplements, smoking, and lung cancer risk. Food Chem Toxicol 194:115104; doi: 10.1016/j.fct.2024.115104. PMID: 39522798.

Haber LT, Bradley MA, Buerger AN, Behrsing H, Burla S, Clapp PW, et al. 2024. New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: Workshop report. Front Toxicol 6:1431790; doi: 10.3389/ftox.2024.1431790. PMID: 39439531.

Russell AJ, Vincent M, Buerger AN, Dotson S, Lotter J, Maier A. 2024. Establishing short-term occupational exposure limits (STELs) for sensory irritants using predictive and in silico respiratory rate depression (RD50) models. Inhal Toxicol 36(1):13-25; doi: 10.1080/08958378.2023.2299867. PMID: 38252504.