Publication Topic

Groff L, Williams A, Shah I, Patlewicz G. 2024. MetSim: Integrated programmatic access and pathway management for xenobiotic metabolism simulators. Chem Res Toxicol 37(5):685-697; doi: 10.1021/acs.chemrestox.3c00398. PMID: 38598715.

Heintz MM, Olack EM, Baldwin WS. Human CYP2B6 is an anti-obesity enzyme that produces active α-linolenic acid metabolites. Society of Toxicology 59th Annual Meeting, Virtual, March 2020.

Olack E, Heintz MM, Baldwin WS. Human CYP2B6 is an anti-obesity enzyme involved in unsaturated fatty acid metabolism. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.

Heintz MM, Kumar R, Rutledge M, Baldwin WS. 2019. Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis. J Nutr Biochem 70(August):125–137; doi: 10.1016/j.jnutbio.2019.05.004. PMID: 31202118.

Heintz MM, Kumar R, Baldwin WS. Cyp2b-null male mice are susceptible to high-fat diet-induced obesity due to changes in PUFA metabolism and response to hepatic lipids as measured by RNAseq. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.

Heintz MM, Kumar R, Baldwin WS. Cyp2b-null male mice are susceptible to high-fat diet-induced obesity due to changes in PUFA metabolism and response to hepatic lipids as measured by RNAseq. American College of Toxicology, 39th Annual Meeting, West Palm Beach, FL, November 2018.

Heintz MM, Kumar R, Baldwin WS. The role of Cyp2b in the metabolism of unsaturated fatty acids. Abstract #1291, Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

McRee R, Heintz MM, Baldwin WS. Inhibition of CYP2B6 does not necessarily alter toxicity except in the case of chemicals with known active metabolites. Abstract #1292, Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

Bi P, Yue F, Karki A, Castro B, Wirbisky SE, Wang C, … Kuang, S. 2016. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med 213(10):2019–2037; doi: 10.1084/jem.20160157. PMID: 27573812.

Robison TW, Jacobs A. 2009. Metabolites in safety testing. Bioanalysis 1(7):1193-1200; doi: 10.4155/bio.09.98.

Robison TW. Dealing with metabolites from an FDA perspective. Ninth Annual Land O’Lakes Bioanalytical Conference: Sponsored by the University of Wisconsin-Madison, Devil’s Head Resort, Merrimac, WI, July 2008.

Staskal DF, DeVito MJ, Ross DG, Birnbaum LS. A comparison of the metabolism of methoxyresorufin, acetanilide, and caffeine in rat and human CYP1A2 SUPERSOMES, Society of Toxicology 42nd Annual Meeting, Salt Lake City, UT, 2003.

Strobel HW, Thompson CM, Antonovic L. 2001. Cytochromes P450 in brain: Function and significance. Curr Drug Metabol 2(2):199–214; doi: 10.2174/1389200013338577. PMID: 11469726.

Leazer TM, Rogers JM. 2001. Role of the acute phase response and tissue necrosis factor alpha in the developmental toxicity of lipopolysaccharide in the CD-1 mouse. Reprod Toxicol 16(2):173–179; doi: 10.1016/S0890-6238(02)00011-4. PMID: 11955948.

Thomas MJ, Robison TW, Forman HJ. 2000. Assessment of tissue injury from reactive oxygen metabolites. In: Chronic Lung Disease in Early Infancy. R.D. Bland and J.J. Coalson, eds. Marcel Dekker, Inc., New York. pp. 779-792.

Gerhardt B, Kordas TJ, Thompson CM, Patel P, Vida TV. 1998. The vesicle transport protein, Vps33p, is an ATP binding protein that localizes to the cytosol in an energy dependent manner. J Biol Chem 273(25):15818–15829; doi: 10.1074/jbc.273.25.15818. PMID: 9624182.

Ramu K, Perry CS, Ahmed T, Pakenham G, and Kehrer JP. 1996. Studies on the basis for the toxicity of acrolein mercapturates. Toxicol Appl Pharmacol 140(2):487-498; doi: 10.1006/taap.1996.0245; PMID: 8887466.

Robison TW, Zhou HF, Forman HJ. 1995. Modulation of ADP-stimulated inositol phosphate metabolism in rat alveolar macrophages by oxidative stress. Arch Biochem Biophys 318(1):215-220; doi: 10.1006/abbi.1995.1223.

Perry CS, Liu XL, Lund LG, Kehrer JP. 1995. Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells. Toxicol in Vitro 9(1):21-26; doi: 10.1016/0887-2333(94)00187-Y. PMID: 20650059.

Robison TW, Freeman L. Nitrogen dioxide-induced formation of arachidonate metabolites from guinea pig tracheobronchial epithelium cultured in an air-interface. American Thoracic Society Annual Meeting, San Francisco, CA, 1993.