Publication Topic

Nguyen HVM, Cabello E, Dyer D, Fender C, Garcia-Jaramillo M, Hord NG, Austad S, Richardson A, Unnikrishnan A. 2025. Age, sex, and mitochrondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat. Aging 17(2):524-549; doi: 10.18632/aging.206211. PMID: 40015964.

Groff L, Williams A, Shah I, Patlewicz G. 2024. MetSim: Integrated programmatic access and pathway management for xenobiotic metabolism simulators. Chem Res Toxicol 37(5):685-697; doi: 10.1021/acs.chemrestox.3c00398. PMID: 38598715.

Frankenfeld CL, Maskarinec G, Franke AA. 2022. Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype. Brit J Nutr 128(8):1490–1498; doi: 10.1017/S0007114521004463. PMID: 34763731.

Werner JA, Davies R, Wahlstrom J, Dahal UP, Jiang M, Stauber J, David B, Siska W…, Monticello TM. 2021. Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat. Toxicol Appl Pharmacol 423(July 15):11578; doi: 10.1016/taap.2021.115578. PMID: 34004237.

Heintz MM, Olack EM, Baldwin WS. Human CYP2B6 is an anti-obesity enzyme that produces active α-linolenic acid metabolites. Society of Toxicology 59th Annual Meeting, Virtual, March 2020.

Frankenfeld CL. 2020. Isoflavones. In: Tomás-Barberán FA, González-Sarrías A, García-Villalba R (eds), Dietary (Poly)Phenols: Their Metabolism and Health Effects. Wiley, ISBN: 9781119563747.

Olack E, Heintz MM, Baldwin WS. Human CYP2B6 is an anti-obesity enzyme involved in unsaturated fatty acid metabolism. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.

Heintz MM, Kumar R, Baldwin WS. Cyp2b-null male mice are susceptible to high-fat diet-induced obesity due to changes in PUFA metabolism and response to hepatic lipids as measured by RNAseq. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.

Heintz MM, Kumar R, Rutledge M, Baldwin WS. 2019. Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis. J Nutr Biochem 70(August):125–137; doi: 10.1016/j.jnutbio.2019.05.004. PMID: 31202118.

Rogers JM. 2019. Smoking and pregnancy: Epigenetics and the developmental origins of the metabolic syndrome. Birth Defects Res 111(17):1259–1269; doi: 10.1002/bdr2.1550. PMID: 31313499.

Heintz MM, Kumar R, Baldwin WS. Cyp2b-null male mice are susceptible to high-fat diet-induced obesity due to changes in PUFA metabolism and response to hepatic lipids as measured by RNAseq. American College of Toxicology, 39th Annual Meeting, West Palm Beach, FL, November 2018.

Heintz MM, Kumar R, Baldwin WS. The role of Cyp2b in the metabolism of unsaturated fatty acids. Abstract #1291, Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

McRee R, Heintz MM, Baldwin WS. Inhibition of CYP2B6 does not necessarily alter toxicity except in the case of chemicals with known active metabolites. Abstract #1292, Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

Bi P, Yue F, Karki A, Castro B, Wirbisky SE, Wang C, … Kuang, S. 2016. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med 213(10):2019–2037; doi: 10.1084/jem.20160157. PMID: 27573812.

Robison TW, Jacobs A. 2009. Metabolites in safety testing. Bioanalysis 1(7):1193-1200; doi: 10.4155/bio.09.98.

Clewell RA, Kremer JJ, Williams CC, Campbell JL, Sochaski MA, Andersen ME, Borghoff SJ. 2009. Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. Toxicology 255(1–2):80–90; doi: 10.1016/j.tox.2008.10.010. PMID: 19010379.

Robison TW. Dealing with metabolites from an FDA perspective. Ninth Annual Land O’Lakes Bioanalytical Conference: Sponsored by the University of Wisconsin-Madison, Devil’s Head Resort, Merrimac, WI, July 2008.

Staskal DF, DeVito MJ, Ross DG, Birnbaum LS. A comparison of the metabolism of methoxyresorufin, acetanilide, and caffeine in rat and human CYP1A2 SUPERSOMES, Society of Toxicology 42nd Annual Meeting, Salt Lake City, UT, 2003.

Strobel HW, Thompson CM, Antonovic L. 2001. Cytochromes P450 in brain: Function and significance. Curr Drug Metabol 2(2):199–214; doi: 10.2174/1389200013338577. PMID: 11469726.

Leazer TM, Rogers JM. 2001. Role of the acute phase response and tissue necrosis factor alpha in the developmental toxicity of lipopolysaccharide in the CD-1 mouse. Reprod Toxicol 16(2):173–179; doi: 10.1016/S0890-6238(02)00011-4. PMID: 11955948.