Publication Topic

Seal S, Trapotsi M, Subramanian V, Spjuth O, Greene N, Bender A. 2025. PKSmart: An open-source computational model to predict in vivo pharmacokinetics of small molecules. J Cheminform 17(1):147; doi: 10.1186/s13321-025-01066-5. PMID: 41013647.

Sakolish C, Moyer H, Barlow N, Roe H, Tsai H, Ford L, Bajaj P, Villenave R, et al. Microphysiological systems as predictive tools for kidney nephrotoxicants: A comparison across four platforms. Abstract 3216, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

Moyer H, Vergara L, Sakolish C, Stephan C, Barlow N, Roe H, Hewitt P, Villenave R, Rusyn I. Comparative analysis of drug permeability and toxicity in intestinal segment-specific membrane-based barrier model using Caco-2 and human jejunal and duodenal enteroid-derived cells. Abstract 3217, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

Sakolish C, Moyer HL, Tsai HD, Ford LC, Dickey AN, Bajaj P, Villenave R, Hewitt P, et al. 2025. Comparative analysis of the physiological and transport functions of various sources of renal proximal tubule cells under static and fluidic conditions in PhysioMimix T12 platform. Drug Metab Dispos 53(1):10001; doi: 10.1124/dmd.124.001488. PMID: 39884810.

Keeton KA, Blanchette A, Benson SM, Covell LT, Madl AK. Analysis and comparison of nicotine pharmacokinetics of modern oral nicotine pouches. Poster Presentation 48 at the 77th Tobacco Science Research Conference, Atlanta, GA, September 2024.

Gawehn E, Greene N, Miljković F, Obrezanova O, Subramanian V, Trapotsi M, Winiwarter S. 2024. Perspectives on the use of machine learning for ADME prediction at AstraZeneca. Xenobiotica 54(7):368-378; doi: 10.1080/00498254.2024.2352598. PMID: 39166404.

Racz L, Mittal L, Perry CS, Blanchette A, Proctor D. Assessing sustainable applications of electric arc furnace steel slag as construction aggregate: Applications of probabilistic risk assessment and physiologically-based pharmacokinetic modeling. Poster presented at Society of Environmental Toxicology and Chemistry North America 44^th Annual Meeting, Louisville, KY, November 2023.

Perry CS, Blanchette AD, Vivanco SN, Verwiel AH, Proctor DM. 2023. Use of physiologically based pharmacokinetic modeling to support development of an acute (24-hour) health-based inhalation guideline for manganese. Regul Toxicol Pharmacol 145:105518; doi: 10.1016/j.yrtph.2023.105518. PMID: 3786341.

Thompson CM, Kirman C, Harris MA. 2023. Derivation of oral cancer slope factors for hexavalent chromium informed by pharmacokinetic models and in vivo genotoxicity data. Regul Toxicol Pharmacol 145(Dec):105521; doi: 10.1016/j.yrtph.2023.105521. PMID: 37863416.

Sakolish C, Moyer H, Fergusson SS, Chiu WA, Rusyn I. Analysis of reproducibility and robustness of PhysioMimix T12, a proximal renal tubule microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs and chemicals. Abstract 3635, Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.

Grover A, Sankaranarayanan S, Mathur V, Suri P, Qiu H, Andrews-Zwilling Y, Mease K, Taylor LK, et al. 2023. Pharmacokinetic and target engagement measures of ANX007, an anti-C1q antibody fragment, following intravitreal administration in nonhuman primates. Invest Opthalmol Visual Sci 64(2)3; 10.1167/iovs.64.2.3. PMID: 36729444.

Kato Y, Lim AY, Sakolish C, Valdiviezo A, Moyer HL, Hewitt P, Bajaj P, Han G, Rusyn I. 2022. Analysis of reproducibility and robustness of OrganoPlate^® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs. Toxicol in Vitro 85(Dec):105464; doi: 10.1016/j.tiv.2022.105464. PMID: 36057418.

Knotts T, Mease K, Sangameswaran L, Felx M, Kramer S, Donovan J. 2022. Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models. J Orthop Res 40(10):2281-2293; doi: 10.1002/jor.25271. PMID: 35128722.

Obrezanova O, Martinsson A, Whitehead T, Mahmoud S, Bender A, Miljković F, Grabowski P,…, Greene N. 2022. Prediction of in vivo pharmacokinetic parameters and time–exposure curves in rats using machine learning from the chemical structure. Molec Pharm 19(5):1488-1504; doi: 10.1021/acs.molpharmaceut.2c00027. PMID: 35412314.

Kato Y, Lim A, Sakolish C, Valdiviezo A, Moyer H, Rusyn I. Testing of reproducibility of a high-throughput liver microphysiological system (OrganoPlate 2-lane plate) for studies of pharmacokinetics and toxicological assessment of drugs. Abstract 4639, Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.

Miljković F, Martinsson A, Obrezanova O, Williamson B, Johnson M, Sykes A, Bender A, Greene N. 2021. Machine learning models for human in vivo pharmacokinetic parameters with in-house validation. Molec Pharm 18(12):4520-4530; doi: 10.1021/acs.molpharmaceut.1c00718. PMID: 34758626.

Ramírez-Valle F, Adams M, Beebe L, Chen J, Chuaqui C, Connarn JN, Corin AF, Dingley KH, et al. 2019. A novel MK2 inhibitor for the treatment of ankylosing spondylitis and other inflammatory diseases. Abstract 1536, Annual Meeting of the American College of Rheumatology Conference, Atlanta, GA, November 2019.

Mihalchik-Burhans AL, Sullivan DW. 2019. Bridging issues of route. In: Gad S (ed), Integrated Safety and Risk Assessment for Medical Devices and Combination Products, pp. 273–297. Springer.

Casey WM, Chang X, Allen DG, Ceger PC, Choksi NY, Hsieh JH, et al. 2018. Evaluation and optimization of pharmacokinetic models for in vitro to in vivo extrapolation of estrogenic activity for environmental chemicals. Environ Health Perspect 126(9):97001; doi: 10.1289/EHP1655. PMID: 30192161.

Thompson CM, Kirman CR, Hays SM, Suh M, Harvey SE, Proctor DM, Rager JE, Haws LC, Harris MA. 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545. PMID: 29064106.