Publication Topic

Lea IA, Rivera B, Rogers S, Borghoff SJ. 2026. Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence. Curr Res Toxicol 10:100284; doi: 10.1016/j.crtox.2026.100284. PMID: 41755915.

Thompson CM, Heintz MM, Cullen JM, Haws LC. 2026. Evaluation of chronic toxicity and carcinogenicity of HFPO-DA in mice. Regul Toxicol Pharmacol 165(Feb):106014; doi: 10.1016/j.yrtph.2025.106014. PMID: 41391658.

Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A, Bus J, Rushton E, Borghoff SJ. 2025. Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Lack of concern based on animal cancer studies and mechanistic data. Curr Res Tox 10(Nov 10):100270; doi: 10.1016/j.crtox.2025.100270. PMID: 41446581.

Thompson CM, Heintz MM, Cullen JM, Haws LC. Evaluation of the chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) in mice. Abstract 4700, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A, Bus J, Rushton EK, Borghoff SJ. Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data. Abstract 4697, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera BN, Fitch S, Buerger A, Choksi N, Franzen A, Bus J, Rushton EK, Lea I. Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data. Abstract 4702, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Covell LT, Han AA, Blanchette AD, Madl AK. Comparison of harmful and potentially harmful constituents (HPHC) and associated excess lifetime cancer risks (ELCR) across oral nicotine products. Abstract 4911, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Blanchette AD, Donnell MT, Covell LT, Madl AK. A machine learning-based framework for predicting carcinogenic potencies for nitrosamine compounds. Abstract 4040, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA. 2025. Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224. PMID: 40084233.

Snodin DJ, Trejo-Martin A, Ponting DJ, Smith GF, Czich A, Cross K, Custer L,… Greene N, et al. 2024. Mechanisms of nitrosamine mutagenicity and their relationship to rodent carcinogenic potency. Chem Res Toxicol 37(2):181-198; doi: 10.1021/acs.chemrestox.3c00327. PMID: 38316048.

Thompson CM, Proctor DM, Harris MA. 2023. Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data.” Environ Mol Mutagen 64(4):259–260; doi: 10.1002/em.22537. PMID: 36916184.

Borghoff SJ, Cohen SS, Jiang X, Lea IA, Klaren WD, Chappell GA, Britt JK, Rivera BN, Choksi NY, Wikoff DS. 2023. Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food Chem Toxicol 172(Feb):113549; doi: 10.1016/j.fct.2022.113549. PMID: 36493943.

Haber LT, Pecquet AM, Vincent MJ, White LM. 2022. The long goodbye: Finally moving on from the relative potency approach to a mixtures approach for polycyclic aromatic hydrocarbons (PAHs). Int J Env Res Pub Health 19(15):9490; doi: 10.3390/ijerph19159490. PMID: 35954852.

Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova NY, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383; doi: 10.1021/acs.chemrestox.1c00291. PMID: 34726909.

Tice RR, Bassan A, Amberg A, Anger LT, Beal MA, Bellion P, Benigni R, Birmingham J…, Mihalchik-Burhans AL, et al. 2021. In silico approaches in carcinogenicity hazard assessment: Current status and future needs. Comp Toxicol 20(Nov):100191; doi: 10.1016/j.comtox.2021.100191. PMID: 35368437.

Thompson CM, Aardema MJ, Heintz MM, MacGregor JT, Young RR. 2021. A review of mammalian in vivo genotoxicity of hexavalent chromium: Implications for oral carcinogenicity risk assessment. Crit Rev Toxicol 51(10)820-849; doi: 10.1080/10408444.2021.2000934. PMID: 35060824.

Erber L, Goodman S, Jokipii Krueger CC, Rusyn I, Tretyakova N. 2021. Quantitative nanoLC/NSI⁺-HRMS method for 1,3-butadiene induced bis-N7-guanine DNA-DNA cross-links in urine. Toxics 9(10):247; doi: 10.3390/toxics9100247. PMID: 34678943.

Jaeschke H, Murray FJ, Monnot AD, Jacobson-Kram D, Cohen SM, Hardisty JF, Atillasoy E… Wikoff D, et al. 2021. Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential. Regul Toxicol Pharmacol 120(March):104859; doi: 10.1016/j.yrtph.2020.104859. PMID: 33388367.

Felter SP, Zhang X, Thompson C. 2021. Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply? Regul Toxicol Pharmacol 121(April):104887; doi: 10.1016/j.yrtph.2021.104887. PMID: 33556417.

Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS. 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150(April):112045; doi: 10.1016/j.fct.2021.112045. PMID: 33587976.