Publication Topic

Wikoff D, Fitch S, Eichenbaum G, Ejaz S, Klaren W, Southall M. Need for fit-for-purpose approaches that integrate dose, mechanism, and context of use with key characteristics when evaluating the carcinogenic potential of widely used therapeutics: A case study of acetaminophen. Abstract 4005, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Lea I, Rivera B, Rogers S, Borghoff SJ. Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence. Abstract 5206, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Buerger AN, Heintz MM, Haws LC, Nyambego H, Palermo CM, Thompson CM. Mode of action and human relevance assessment for diisononyl phthalate (DINP)-induced liver tumors in rodents. Abstract 3324, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Buerger AN, Lea IA, Vincent MJ,…, Choksi NY, Britt J, Fitch S, Rogers S, Schaefer H, Haws L,…, Wikoff D, Borghoff SJ. Systematic evaluation of the carcinogenic potential of di-isononyl phthalate in humans. Abstract 3314, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Lea IA, Rivera B, Rogers S, Borghoff SJ. 2026. Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence. Curr Res Toxicol 10:100284; doi: 10.1016/j.crtox.2026.100284. PMID: 41755915.

Thompson CM, Heintz MM, Cullen JM, Haws LC. 2026. Evaluation of chronic toxicity and carcinogenicity of HFPO-DA in mice. Regul Toxicol Pharmacol 165(Feb):106014; doi: 10.1016/j.yrtph.2025.106014. PMID: 41391658.

Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A, Bus J, Rushton E, Borghoff SJ. 2025. Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Lack of concern based on animal cancer studies and mechanistic data. Curr Res Tox 10(Nov 10):100270; doi: 10.1016/j.crtox.2025.100270. PMID: 41446581.

Thompson CM, Heintz MM, Cullen JM, Haws LC. Evaluation of the chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) in mice. Abstract 4700, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A, Bus J, Rushton EK, Borghoff SJ. Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data. Abstract 4697, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera BN, Fitch S, Buerger A, Choksi N, Franzen A, Bus J, Rushton EK, Lea I. Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data. Abstract 4702, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Covell LT, Han AA, Blanchette AD, Madl AK. Comparison of harmful and potentially harmful constituents (HPHC) and associated excess lifetime cancer risks (ELCR) across oral nicotine products. Abstract 4911, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Blanchette AD, Donnell MT, Covell LT, Madl AK. A machine learning-based framework for predicting carcinogenic potencies for nitrosamine compounds. Abstract 4040, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA. 2025. Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224. PMID: 40084233.

Snodin DJ, Trejo-Martin A, Ponting DJ, Smith GF, Czich A, Cross K, Custer L,… Greene N, et al. 2024. Mechanisms of nitrosamine mutagenicity and their relationship to rodent carcinogenic potency. Chem Res Toxicol 37(2):181-198; doi: 10.1021/acs.chemrestox.3c00327. PMID: 38316048.

Thompson CM, Proctor DM, Harris MA. 2023. Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data.” Environ Mol Mutagen 64(4):259–260; doi: 10.1002/em.22537. PMID: 36916184.

Borghoff SJ, Cohen SS, Jiang X, Lea IA, Klaren WD, Chappell GA, Britt JK, Rivera BN, Choksi NY, Wikoff DS. 2023. Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food Chem Toxicol 172(Feb):113549; doi: 10.1016/j.fct.2022.113549. PMID: 36493943.

Haber LT, Pecquet AM, Vincent MJ, White LM. 2022. The long goodbye: Finally moving on from the relative potency approach to a mixtures approach for polycyclic aromatic hydrocarbons (PAHs). Int J Env Res Pub Health 19(15):9490; doi: 10.3390/ijerph19159490. PMID: 35954852.

Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova NY, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383; doi: 10.1021/acs.chemrestox.1c00291. PMID: 34726909.

Tice RR, Bassan A, Amberg A, Anger LT, Beal MA, Bellion P, Benigni R, Birmingham J…, Mihalchik-Burhans AL, et al. 2021. In silico approaches in carcinogenicity hazard assessment: Current status and future needs. Comp Toxicol 20(Nov):100191; doi: 10.1016/j.comtox.2021.100191. PMID: 35368437.

Thompson CM, Aardema MJ, Heintz MM, MacGregor JT, Young RR. 2021. A review of mammalian in vivo genotoxicity of hexavalent chromium: Implications for oral carcinogenicity risk assessment. Crit Rev Toxicol 51(10)820-849; doi: 10.1080/10408444.2021.2000934. PMID: 35060824.