2021
Chappell GA , Heintz MM , Haws LC . 2021. Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action underlying liver tumor development. Curr Res Toxicol 2:30–41.
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Publication: Manuscripts
Perry C, Rish W, Ring C, Mittal L, Harris M . Use of probabilistic risk assessment and physiologically based pharmacokinetic modeling in supporting soil remedial objectives for dioxins and furans at a Canadian site. Poster for Society for Risk Analysis, Virtual Annual Meeting, 2020.
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Publication: Abstracts and Presentations
Chappell GA , Wikoff DS , Thompson CM . 2021. Assessment of mechanistic data for hexavalent chromium-induced rodent intestinal cancer using the key characteristics of carcinogens. Toxicol Sci (ms. online ahead of print).
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Publication: Manuscripts
2020
Wikoff DS , Urban JD , Ring C , Britt J , Fitch S , Haws LC . 2020. Development of a range of plausible non-cancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on effects on sperm count: Application of systematic review methods and quantitative integration of dose response using meta-regression. Toxicol Sci (Advance Access ).
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Publication: Manuscripts
Bhat VS , Cohen SM, Gordon EB, Wood CE, Cullen JM, Harris MA , Proctor DM , Thompson CM . 2020. An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: A case study with hexavalent chromium, captan, and folpet. Crit Rev Toxicol 50(8) (open access) .
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Publication: Manuscripts
Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D , Atillasoy E. 2020. Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. Regul Toxicol Pharmacol 118:104788.
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Publication: Manuscripts
Fryzek J , Bylsma L , Mease K , Movva N , Welsh BT , Wood M . 2020. Critical insights into nonclinical toxicology and real-world evidence essential for a successful rare disease product launch. EpidStrategies, Inc., white paper.
White Paper
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Publication: White paper
Mahony CA, Bowtell P, Huber M, Kosemund K, Pfuhler S, Zhu T, Barlow S, McMillan DA . 2020. Threshold of toxicological concern (TTC) for botanicals — Concentration data analysis of potentially genotoxic constituents to substantiate and extend the TTC approach to botanicals. Food Chem Toxicol 138:111182.
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Publication: Manuscripts
Chorley BN, Carswell GK, Nelson G, Bhat VS , Wood CE. 2020. Early microRNA indicators of PPARα pathway activation in the liver. Toxicol Rep 7:805–815.
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Publication: Manuscripts
Henderson RG, Franzen A, Franke K, Payne L , Schmitt D, Wikoff D. Creating a literature database for cannabidiol (CBD): Systematic evidence mapping. Poster for Society of Toxicology , Virtual Annual Meeting, 2020.
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