Publication Topic

Suh M, Casteel S, Dunsmore M, Ring C, Verwiel A, Proctor DM. 2019. Bioaccessibility and relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations. Sci Tot Environ 660:677–689.

Tsaioun K, Dirven H, Beck Færden K, Wikoff D, Ram R, Kleinstreuer N, McCormack A, Wright R, Vist GE, Fitch S. 2018. Systematic reviews of the hepatotoxic effects of specified compounds/drugs as observed in humans and experimental animals (rats, mice, dogs and non-human primates). PROSPERO CRD42018112353.

Borghoff SJ, Fitch S, Rager JE, Huggett D. 2018. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regul Toxicol Pharmacol 99:168–181.

Ring CL, Suh M, Casteel S, Dunsmore M, Verwiel A, Proctor D. Relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations. Presented at Joint Annual Meeting of International Society of Exposure Science and International Society for Environmental Epidemiology (ISES-ISEE 2018), Ottawa, Canada, August 2018.

Harrill AH, Borghoff S, Zorrilla L, Blystone C, Kissling GE, Malarkey D, Shockley K, Travlos G, DeVito MJ. 2018. NTP Research Report on baseline characteristics of Diversity Outbred (J:DO) mice relevant to toxicology studies. National Toxicology Program Research Report 6, Research Triangle Park, NC.

Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh J-H, Auerbach SS, Rager JE. 2018. Identifying attributes that influence in vitro-to-in vivo concordance by comparing in vitro Tox21 bioactivity versus in vivo DrugMatrix transcriptomic responses across 130 chemicals. Toxicol Sci kfy220, available at https://doi.org/10.1093/toxsci/kfy220.

Wikoff DS, Thompson C, Rager J, Chappell G, Fitch S, Doepker C. 2018. Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates. Food Chem Toxicol 120:709-723.

Phillips MB, Balbuena-Venancio P, Enders JR, Norini RL, Shim Y-S, Burgunder E, Rao L, Billings D, Pedersen J, Macdonald JM, Andersen M, Clewell HJ 3^rd, Yoon M. 2018. Xenobiotic metabolism in alginate-encapsulated primary human hepatocytes over long timeframes. Appl in Vitro Toxicol 4(3), DOI: https://doi.org/10.1089/aivt.2017.0029.

Borghoff S, Wikoff D, Urban JD, Rager JE. A systematic approach to identify plausible mode-of-actions (MOA) for an increased incidence of lung tumors in mice with chronic exposure to 4-methylimidazole (4-MEI). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

Wikoff DS, Miller GW. 2018. Systematic reviews in toxicology (Editorial). Toxicol Sci 163(2):335–337.

Hartman JK, Beames T, Parks B, Doheny D, Song G, Efremenko A, Yoon M, Foley B, Deisenroth C, McMullen PD, Clewell RA. 2018. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis. Toxicol Appl Pharmacol 355:112-126.

Thompson CT, Suh M, Chappell G, Borghoff S, Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor, DM. 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189 doi: 10.1016/j.yrtph.2018.05.006.

Suh M, Proctor DM, Chappell G, Rager JE, Thompson CM, Borghoff S, Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicology 402-403:50-67, doi: 10.1016/j.tox.2018.04.006.

Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96:30-40, doi: 10.1016/j.yrtph.2018.04.016.

Hedges L, Brown S, Vardy A, Doyle E, Yoon M, Osimitz TG, Lake BG. 2018. Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations. Xenobiotica published online. Doi: 10.1080/00498254.1451011.

Brorby GP. 2018. The ongoing controversy surrounding the effects of short-term exposure to trichloroethene. Presented at the Association for Environmental Health and Sciences Foundation Annual International Conference, March 19–22, San Diego, CA.

Wikoff D, Urban JD, Harvey S, Haws LC. 2018. Role of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene. Int J Toxicol, DOI: 0.1177/1091581818754330.

Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C, Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; DOI: 10.1021/acs.chemrestox.7b00221.

Ring CL, Pearce RG, Setzer RW, Wetmore BA, Wambaugh JF. 2017. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability. Environ Int 106:105–118.

Bichteler A, Wikoff DS, Loko F, Harris MA. 2017. Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data. Environ Int 105(2017):112-125.

Ramoju SP, Mattison DR, Milton B, McGough D, Shilnikova N, Clewell HJ, Yoon M, Taylor MD, Krewski D, Andersen ME. 2017. The application of PBPK models in estimating human brain tissue manganese concentrations. Neurotoxicology 58:226–237.

Song G, Sun X, Hines RN, McCarver DG, Lake BG, Osimitz TG, Creek MR, Clewell HJ, Yoon M. 2017. Determination of human hepatic CYP2C8 and CYP1A2 age-dependent expression to support human health risk assessment for early ages. Drug Metab Disposit 45(5):468–475

Kirman CR, Suh M, Proctor DM, Hays SM. 2017. Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations. Toxicol Appl Pharmacol 325:9-17.

Wikoff DS, Rager J, Harvey S, Haws L, Chappell G, Borghoff S. 2017. Framework for quantitative consideration of study quality and relevance in the systematic evaluation of mechanistic data per the Ten Key Characteristics of Carcinogens. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

Ngueta G, Longnecker MP, Yoon M, Ruark CD, Clewell HJ Rd, Andersen ME, Verner MA. 2017. Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use. Environ Int 104:118–121.

Moreau M, Leonard J, Phillips K, Campbell J, Pendse S, Nicolas C, Phillips M, Yoon M, Tan Y-M, Smith S, Pudukodu H, Isaacs K, Clewell H. 2017. Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates. Chemosphere 184:1194–1201.

Clippinger AJ, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G, Melbourne J, Hinderliter P, Yoon M, Huh D, Lowit A, Buckley B, Bartels M, BéruBé K, Wilson DM, Indans I, Vinken M. 2017. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicol In Vitro 48:53–70. doi: 10.1016/j.tiv.2017.12.011. PubMed PMID: 2927765

Thompson CM, Wolf, JC, McCoy A, Suh M, Proctor DM, Kirman CR, Haws LC, Harris MA. 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101. DOI: 10.1177/019262331yy4324.

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Chjoksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS. 2017. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol in Vitro 47:213–227.

Borghoff SJ, Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes.  J Appl Toxicol, DOI 10.1002/jat.3412

Yoon M, Clewell HJ 3rd. 2016. Addressing early life sensitivity using physiologically based pharmacokinetic modeling and in vitro to in vivo extrapolation. Toxicol Res 32(1):15–20.

Yoon M, Adeleye Y, Clewell R, Jennings P, Whelan M. 2016. Roundtable discussion: Moving beyond prioritization toward true in vitro safety assessment. Appl In Vitro Toxicol 2(2):67–73.

Pedersen JM, Shim YS, Hans V, Phillips MB, Macdonald JM, Walker G, Andersen ME, Clewell HJ 3rd, Yoon M. 2016. Fluid dynamic modeling to support the development of flow-based hepatocyte culture systems for metabolism studies. Front Bioeng Biotechnol 4:72.

Yoon M, Adeleye Y, Clewell R, Jennings P, Whelan M. 2016. Moving beyond prioritization toward true in vitro safety assessment. Appl In Vitro Toxicol 2(2):67–73.

Wikoff DS, Britt JK.  2016. The role of systematic review in the practice of toxicology and risk assessment – An appreciation for the primary tool in evidence-based approaches.  Toxicology: Open Access 2(110):1-4. 

Schmitt D, Levy R, Carroll B. 2016. Toxicological evaluation of ß-caryophyllene oil: Subchronic toxicity in rats. Int J Toxicol 35(5):558–567.

Yoon M, Clewel H 3rd, Blaauboer BJ (Eds). 2015. Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment. Toxicology 332:1–124.

Yoon M, Taylor MD, Clewell HJ, Andersen ME. 2015. Modeling manganese kinetics for human health risk assessment. In: Issues in Toxicology, Vol 2015-January, Issue 22, Royal Society of Chemistry, pp 322–354.

Campbell JL, Yoon M, and Clewell HJ 3^rd. 2015. A case study on quantitative in vitro to in vivo extrapolation for environmental esters: Methyl-, propyl- and butylparaben. Toxicology 332:67–76.

Yoon M, Kedderis GL, Yan GZ, and Clewell HJ 3^rd. 2015. Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study. Toxicology 332:52–66.

Yoon M, Blaauboer BJ, and Clewell HJ. 2015. Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment. An editorial for the Special Issue in Toxicology 332:1–3.

Wu H, Yoon M, Verner MA, Xue J, Luo M, Andersen ME, Longnecker MP, Clewell HJ 3rd. 2015. Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics? Environ Int 82:61–68.

Brown K, Phillips M, Grulke C, Yoon M, Young B, McDougall R, Leonard J, Lu J, Lefew W, Tan YM. 2015. Reconstructing exposures from biomarkers using exposure-pharmacokinetic modeling—A case study with carbaryl. Regul Toxicol Pharmacol 73(3):689–698.

Verner MA, Loccisano AE, Morken NH, Yoon M, Wu H, McDougall R, Maisonet M, Marcus M, Kishi R, Miyashita C, Chen MH, Hsieh WS, Andersen ME, Clewell HJ 3rd, Longnecker MP. 2015. Associations of perfluoroalkyl substances (PFAS) with lower birth weight: An evaluation of potential confounding by glomerular filtration rate using a physiologically based pharmacokinetic model (PBPK). Environ Health Persp 123(12):1317–1324.

Ramani T, Auletta CS, Weinstock D, Mounho-Zamora B, Ryan PC, Salcedo TW, Bannish G. 2015. Cytokines: The good, the bad, and the deadly. Int J Toxicol 34(4):355–365, DOI 10.1177/1091581815584918.

Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308. doi: 10.1002/jat.3132.

Kirman CR, Proctor D, Suh M, Thompson CM, Harris MA, Haws LC, Hays SM. 2014. Variation analysis of PBPK model parameters for describing the delivery of Cr(VI) to the small intestines of humans. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Johnson GE, Soeteman-Hernandez, Gollapudi BB, Bodger OG, Dearfield KL, RH Heflich, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. 2014. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Molec Mutagen 55(8):609-623. doi: 10.1002/em.21870/em.21870.

Faber W, Kirkpatrick D, Coder P, Li P, Borghoff S, Banton M. 2014. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regul Toxicol Pharmacol 68:332-342.

Clewell HJ, Yoon M. 2014. In vitro–in vivo extrapolation. In: Wexler P (Ed), Encyclopedia of Toxicology, 3rd Edition, Vol 2. Elsevier Inc., Academic Press, pp. 1096–1100.

Yoon M, Efremenko A, Blaauboer B, Clewell HJ 3^rd. 2014. Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds. Toxicol in Vitro 28(2):164–170.

Phillips MB, Yoon M, Young B, Tan Y-M. 2014. Analysis of biomarker utility using a PBPK/PD model for carbaryl. Front Pharmacol 5:246.

Suh M, Troese MJ, Hall DA, Yasso B, Yzenas JJ, Proctor DM. 2014. Evaluation of electric arc furnace-processed steel slag for dermal corrosion, irritation, and sensitization from dermal contact. J Appl Toxicol 34(12):1418-1425. DOI: 10.1002/jat.2974.

Yoon M, Clewell HJ, and Andersen ME. 2013. Deriving an explicit hepatic clearance equation accounting for plasma protein binding and hepatocellular uptake. Toxicol in Vitro 27(1):11–15.

Yan GZ, Generaux CN, Yoon M, Goldsmith RB, Tidwell RR, Hall JE, Olson CA, Clewell HJ, Brouwer KL, Paine MF. 2012. A semi-physiologically-based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair. Drug Metab Dispos 40:6–17.

Taylor M, Clewell HJ, Andersen ME, Schroeter JD, Yoon M, Keene AM, Dorman DC. 2012. Update on a pharmacokinetic-centric alternative Tier II program for MMT. Part II. Physiologically based pharmacokinetic modeling and manganese risk assessment. J Toxicol, Article ID 791431, 17 p.

Yoon M, Kedderis G, Yang Y, Allen B, Yan G, and Clewell H. 2012. Use of in vitro data in PBPK models: An example of in vitro to in vivo extrapolation with carbaryl. In Knaak JB, Timchalk C, Tornero-Velez R (Eds), Parameters for Pesticide QSAR and PBPK/PD models for Human Risk Assessment. Vol. 1099, pp. 323–338, American Chemical Society.

Yoon M, Campbell J, Andersen M and Clewell H. 2012. Quantitative in vitro to in vivo extrapolation of cell-based toxicity assays results. Crit Rev Toxicol 42(8):633–652.

Schroeter J, Dorman D, Yoon M, Nong A, Taylor M, Andersen M, Clewell H. 2012. Application of a multi-route physiologically-based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys. Toxicol Sci 129:432–446.

Henderson RG, Durando J, Oller A, Merkel DJ, Marone PA,  Bates HK. 2012. Acute oral toxicity of nickel compounds. Regul Toxicol Pharmacol 62(3):425-432.

Gentry PR, Clewell HJ 3rd, Clewell R, Campbell J, Van Landingham C, Shipp AM. 2011. Challenges in the application of quantitative approaches in risk assessment: A case study with di-(2-ethylhexyl)phthalate. Crit Rev Toxicol 41(Suppl 2):1–72.

Schroeter JD, Nong A, Yoon M, Taylor MD, Dorman DC, Andersen ME, and Clewell, HJ 3^rd. 2011. Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically-based pharmacokinetic models. Toxicol Sci 120(2):481–498.

Yoon M, Schroeter JD, Nong A, Taylor MD, Dorman DC, Andersen ME, and Clewell, HJ 3^rd. 2011. Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: Describing manganese homeostasis during development. Toxicol Sci 122: 297–316.

Nong A, Taylor MD, Yoon M, Andersen ME. 2010. Pharmacokinetic modeling of manganese—An essential element. In: Quantitative Modeling in Toxicology, Krishnan K, Andersen ME (Eds), John Wiley & Sons.

Yoon M, Nong A, Clewell HJ 3rd, Taylor MD, Dorman DC, Andersen ME. 2009. Lactational transfer of manganese in rats: Predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model. Toxicol Sci 112(1):23–43.

Yoon M, Nong A, Clewell HJ 3rd, Taylor MD, Dorman DC, Andersen ME. 2009. Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model. Toxicol Sci 112(1):44–58.

Yoon M, Barton HA. 2008. Predicting maternal rat and pup exposures: How different are they? Toxicol Sci 102(1):15–32.

Lim SJ, Jung YS, Yoon MY, Kim YC. 2007. Comparative effects of dimethylsulfoxide on metabolism and toxicity of carbon tetrachloride and dichloromethane. J Appl Toxicol 27(1):25–31.

Yoon M, Madden MC, Barton HA. 2007. Extrahepatic metabolism by CYP2E1 in PBPK modeling of lipophilic volatile organic chemicals: Impacts on metabolic parameter estimation and prediction of dose metrics. J Toxicol Environ Health, Part A 70:1527–1541.

Yoon MY, Lee SJ, Lee BH, Chung JH, Kim YC. 2006. Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice. Biol Pharmaceut Bull 29(8):1618–1624.

Yoon M, Madden MC, Barton HA. 2006. Developmental expression of aldehyde dehydrogenase in rat: A comparison of liver and lung development. Toxicol Sci 89(2):386–398.

Yoon M, Park S, Park T. 2001. Stress-induced changes of taurine transporter activity in the human colon carcinoma cell line (HT-29). Korean J Nutr 34(2):150–157.

Yoon M, Jung H, Lee H, Park T. 2001. Beta-alanine induced down-regulation of the taurine transporter activity in the human colon carcinoma cell line (HT-29). J Korean Soc Food Sci Nutr 30(2):314–319.

Kim SK, Kim SY, Yoon MY, Oh SJ, Kim HS, Lee JY, Kang SA, Lee KH, Kim YC. 2000. Chronic toxicity of a combined preparation of ticlopidine and Ginkgo biloba extract (EGb) orally administered to rats for 13 consecutive weeks. J Toxicol Public Health 16(4):293–301.

Kim SN, Kim SY, Yim HK, Lee WY, Ham KS, Kim SK, Yoon MY, Kim YC. 1999. Effect of dimethyl-4, 4’-dimethoxy-5, 6,5’, 6’-dimethylenedioxybipheny-2,2′-dicarboxylate (DDB) on chemical-induced liver injury. Biol Pharmaceut Bull 22(1):93–95.

Yim HK, Kim SN, Kim SK, Kim SY, Yoon MY, Kang SA, Kim YC. 1998. Acute oral toxicity of a combined preparation of ticlopidine and Ginkgo biloba extract in rats. J Toxicol Public Health 14(1):119–122.

Kim SY, Yim HK, Yoon MY, Kim SK, Lee JY, Oh SJ, Kim HS, Kang SA, Kim YC. 1998. Subchronic toxicity of a combined preparation of ticlopidine and Ginkgo biloba extract orally administered to rats for 30 days. J Toxicol Public Health 14(4):547–555.

Yoon MY, Kim YC. 1997. Acute toxicity of pectenotoxin 2 and its effects on hepatic metabolizing enzyme system in mice. Korean J Toxicol 13(3):183–186.

Yoon MY, Kim SN, Kim YC. 1997. Potentiation of acetaminophen hepatotoxicity by acute physical exercise in rats. Res Comm Molec Pathol Pharmacol 96(1):35–44.

Yoon MY, Kim YC. 1997. Toxicity and changes in hepatic metabolizing enzyme system induced by repeated administration of Pectenotoxin 2 isolated from marine sponges. Korean J Pharmacol 28(4):280–285.

Yoon MY, Kim YC. 1994. Effects of acute physical exercise on acetaminophen hepatotoxicity in female rats. Korean J Toxicol 10(2):333–340.