Publication Topic

Covington TR, Borghoff SJ, Bacigalupi L, O’Neal S, Cook B, Nelms M, et al. Prediction of chemical suitability for screening in a high-throughput assay platform using an in silico mass balance model. American Society of Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, October 2024.

Burnett J, Sychterz C, Zhu D, Shakeel F, Dingley K, Chen W, et al. Prospective application of physiologically based pharmacokinetic (PBPK) modeling to inform the design of a clinical drug-drug interaction (DDI) study: Case study of mezigdomide. Poster presented at American Society of Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting, Colorado Springs, CO, March 2024.

Price S, Maddaloni M, Finley B, Thornton S, Unice K. 2023. Extending regulatory biokinetic lead models towards food safety: Evaluation of consumer baby food contribution to infant blood lead levels and variability. Foods 12(14):2732; 103390/foods12142732. PMID: 37509824.

Lawrenz M, Svensson M, Kato M, Dingley K, et al. 2023. A computational physics-based approach to predict unbound brain-to-plasma partition coefficient, Kp,uu. Chem Inf Model 63(12):3786–3798; doi: 10.121/acs.jcim.3c00150. PMID: 37267072.

East A, Egeghy PP, Cohen Hubal EA, Slover R, Vallero DA. 2023. Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model. J Expos Sci Environ Epidemiol 33(1):56-68; doi:10.1038/s41370-021-00374-w. PMID: 34373583.

Yin W, Nie Z, Dingley K, Trzoss M, Krilov G, Marshall N et al. 2021. Characterization of potent paracaspase MALT1 inhibitors for hematological malignancies. Blood 138 (Supplement 1):1187; doi: 10.1182/blood-2021-153159.

Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE, Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. 2021. Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Sci Reports 11(1)6403; doi: https://doi.org/10.1038/s41598-021-85708-2. PMID: 33737635.

Zorn KM, Foil DH, Lane TR, Hillwalker W, Feifarek DJ, Jones F, Klaren WD, Brinkman AM, Ekins S. 2020. Comparison of machine learning models for the androgen receptor. Environ Sci Technol 54(21):13690–13700; doi: 10.1021/acs.est.0c03984. PMID: 33085465.

Walz E, Middleton J, Sampedro F, VanderWaal K, Malladi S, Goldsmith T. 2020. Modeling the transmission of foot and mouth disease to inform transportation of infected carcasses to a disposal site during an outbreak event. Front Vet Sci 6:501; doi: 10.3389/fvets.2019.00501.

Sedykh A, Choksi N, Allen D, Kleinstreuer N, Casey W, Shah R. Mixture-based modeling of chemical ocular toxicity based on the US EPA hazard categories. Poster presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019

Cyrs WD, Dussex D, Glynn M, Finley BL. Benchmark dose modeling for respiratory irritation from 2,3-pentanedione exposure. Podium presentation at American Industrial Hygiene Conference & Exposition (AIHce), 2016.

Glynn ME, Adams RE, Beckett EM, Scott PK, Pierce JS, Finley BL. Human equivalent concentrations for diacetyl based on minimal bronchiolar respiratory effects observed in animals: A refined analysis using current toxicology data and dosimetry models. Abstract #1300. Poster presentation at Society of Toxicology 55^th Annual Meeting, New Orleans, LA, 2016.

Cowan DM, Maskrey JR, Fung E, Woods T, Stabryla L, Scott PK, Finley BL. Evaluation of empirically-based PBPK modeling approaches for modeling ante- and post mortem ethanol concentrations in biological matrices. Poster presentation Society of Toxicology 54^th Annual Meeting, San Diego, CA, 2015.

Monnot AD, Christian WV, Paustenbach DJ, Finley BL. 2014. Correlation of blood Cr(III) and adverse health effects: Application of PBPK modeling to determine non-toxic blood concentrations. Crit Rev Toxicol 44(7):618–637; doi:10.3109/10408444.2014.926472. PMID: 25068491.

Unice KM, Monnot AD, Gaffney SH, Tvermoes BE, Thuett KA, Paustenbach DJ, Finley BL. 2012. Inorganic cobalt supplementation: Prediction of cobalt levels in whole blood and urine using a biokinetic model. Food Chem Toxicol 50(7):2456–2461; doi: 10.106/j.fct.2012.04.009. PMID: 22538081.

Finley BL, Monnot AD, Gaffney SH, Paustenbach DJ. 2012. Dose-response relationships for blood cobalt concentrations and health effects: A review of the literature and application of a biokinetic model. J Toxicol Environ Health B, 15(8):493–523; doi: 10.1080/10937404.2012.744287.

Knutsen JS, Kerger BD, Finley BL, Paustenbach DJ. 2012. A calibrated human PBPK model for benzene inhalation with urinary bladder and bone marrow compartments. Risk Anal 33 (7):1237–1251; doi: 10.1111/j.1539-6924.2012.01927.x. PMID: 23278103.

Kirman CR, Hays SM, Aylward LL, Suh M, Proctor D. 2012. Physiologically-based pharmacokinetic model for mice, rats and humans orally-exposed to chromium. Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.

Wikoff DS, Thompson C, Walker N, DeVito M, Harris M, Birnbaum L, Haws L. Derivation of relative potency estimates using benchmark dose modeling: A case study with TCDF. Presented at Dioxin 2011, Brussels, Belgium, August 2011.

Johns DO, Owens EO, Thompson CM, Sonawane B, Hattis D, Krishnan K. 2010. Physiological parameters and databases for PBPK modeling. Chapter 5 in: Quantitative Modeling in Toxicology. Krishnan K, Andersen M (eds.). Wiley, p. 107.