In accordance with their Endocrine Disruption Screening Program (EDSP), the EPA recently released the Tier 1 screening data for various pesticide chemicals. In these Tier 1 assays, 52 pesticide chemicals were tested to determine their potential to interact with hormone pathways. Of the 52 chemicals evaluated, there was no evidence for potential interaction with any of the endocrine pathways tested for 20 chemicals. Fourteen chemicals showed potential interaction with one or more pathways, but EPA already has enough information to conclude that they do not pose a risk. Of the remaining 18 chemicals, all 18 showed potential interaction with the thyroid pathway, 17 of them with the androgen pathway, and 14 with the estrogen pathway. The EPA will decide which of these pesticides will move on to Tier 2 testing.
ToxStrategies’ own Dr. Susan Borghoff assisted in the EDSP, having implemented more than 40 studies associated with the Tier 1 screening visit this site right here. As an expert in endocrine disruption, Dr. Borghoff is often cited for her organization of a 2013 workshop, Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program, detailing the information and progress made in the EDSP. Dr. Borghoff organized and chaired a symposium at the 2013 American College of Toxicology Meeting entitled Endocrine Disruption Screening – Status of the U.S. EPA and EU Programs: State of the Science and Slate for the Future in which she presented a talk entitled The U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 Assays: Retrospective Performance Evaluation.
Dr. Borghoff is well versed in evaluating chemical-specific data from the EPA’s EDSP21 ToxCast database which contains the results of the estrogen and androgen specific in vitro assays. She also has experience in the development and preparation of “Other Scientifically Relevant Information” (OSRI) documents to determine if specific Tier I assays can be waived and or providing an approach to evaluate the weight of evidence for Tier 2 testing.
For more information on the EDSP Tier 1 Assessments, please click here.