ToxStrategies scientists have developed a range of plausible toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on application of systematic review methods and quantitative integration of dose response using meta-regression. This research is being published in the journal Toxicological Sciences and will advance risk assessments involving this class of compounds, providing important information to guide risk-based decision-making.