Understanding the Full Picture of Chemical and Environmental Exposures
Regulators, industry, and the public are increasingly focused on the combined effects of multiple chemicals and environmental stressors on human health. Recently, the Make Our Children Healthy Again Assessment The MAHA Report – The White House identified exposure to an “aggregation of environmental chemicals” and exposure to food additives among the key drivers behind child health issues. Traditional “aggregate” risk assessments have estimated exposures to individual chemicals through multiple pathways, then added risks together. Today, the science — and the regulations — are moving further, toward true cumulative risk assessment (CRA).
In early 2025, the U.S. Environmental Protection Agency released new CRA guidance and applied it in a draft assessment for five phthalates, considering combined exposures and effects from the substances including those from “non-TSCA exposures,” such as dietary intake Draft Proposed Approach for Cumulative Risk Assessment of High-Priority Phthalates and a Manufacturer-Requested Phthalate under the Toxic Substances Control Act. These advances highlight the growing need for technical expertise in evaluating the combined life course exposures and risks from multiple chemicals, multiple sources, and even non-chemical stressors.
Our Expertise
At ToxStrategies, we help clients meet this challenge with proven methods, advanced models, and deep regulatory insight. We have delivered tailored cumulative risk assessments for:
- Multiple Routes & Sources – Oral (dietary and incidental), inhalation, and dermal exposures from air, water, soil, food, products, and other sources. We apply models such as SEEM and CARES NG with data from NHANES, CPDat, and ChemExpo.
- Lifetime Exposure Profiles – Using SHEDS and PBPK modeling to predict total chemical exposures and internal doses across life stages.
- Chemistry-Specific Approaches– Assessing mode of action, determining relative potency factors, and other methods of assessing hazard for substances such as dioxins, phthalates, and a variety of food ingredients.
- Consumer Product Assessments – Applying PACEM and CONSEXPO to evaluate aggregate and cumulative exposure from personal care and household products; assessing risk across health outcomes for mixtures and multi-ingredient products.
- Pesticide & Agricultural Applications – Leveraging EPA Office of Pesticide Programs models to assess diverse pathways, from handler exposure to dietary intake.
Why Clients Choose Us
- Recognized leaders in exposure science, toxicity assessment, and quantitative risk assessment.
- Direct experience with the latest U.S. EPA and international CRA guidance.
- Ability to translate complex data into actionable insights for decision-making.
The science of cumulative risk assessment is complex. ToxStrategies’ experts are ready to help you navigate this evolving regulatory landscape with state-of-the-art knowledge, credibility, and clarity. For more information contact Daniele Wikoff (dwikoff@toxstrategies.com) or Julie Panko (jpanko@toxstartegies.com).