Author Archives: ToxStrategies

Dr. Kirby Tyndall, Mrs. Camarie Perry, and Ms. Alea Goodmanson will be at the annual TCEQ Environmental Trade Fair & Conference next week in Austin, TX.  They’re looking forward to seeing some familiar faces and meeting new people. Stop by and visit them at booth #527!

ToxStrategies’ scientists continue to develop innovative solutions to address some of the most challenging scientific issues that face our clients buy xenical.  Several recent examples of such projects will be presented at the Society of Toxicology 55th Annual Meeting. The SOT 2016 conference will be in New Orleans the week of March 13-27, 2016. To see a schedule of our presentations, click here.  If you will be present in New Orleans, come by and visit with us at our presentations.  If you will not be in attendance, but would like to receive a copy of a particular presentation, reply to this email with your request and we will send you a copy of the presentation at the conclusion of the meeting. Additionally, ToxStrategies will be exhibiting at the ToxExpo. Visit us at Booth #948 to learn more about our services and meet members of our staff.

ToxStrategies will be attending and exhibiting at the International Production & Processing Expo (IPPE) in Atlanta, GA from January 26 to January 28, 2016.

IPPE is one of the largest annual trade shows for the poultry, meat and feed industry. It is a collaboration of three shows: the International Poultry Expo, the International Meat Expo, and the International Feed Expo. IPPE focuses on:

• Innovation – presenting the latest technology of product and services
• Education – providing seminars on topics that cross industry interests from production to regulation
• Global Reach – more than 7,000 international visitors representing over 100 countries will attend
• Networking – provides opportunities to collaborate with leaders from various aspects of protein processing and production

ToxStrategies scientists, Alea T xenical diet pills. Goodmanson and Jodi Miller, are looking forward to meeting new people and seeing a few familiar faces. Stop by and visit them at booth #3010!

For more information on the education program, the trade show, or other meeting details, please click here.

ToxStrategies’ Health Sciences Practice Leader, Dr. Daniele Wikoff was an invited speaker at EPA’s ‘Advancing Systematic Review for Chemical Risk Assessment’ workshop held in Arlington, VA on December 16-17, 2015.  Dr. Wikoff presented ‘Lessons learned in protocol development and implementation of multi-endpoint systematic reviews’ and participated in a panel discussion on the integration of mechanistic data in a systematic review.

The goal of this workshop, was to facilitate discussion on both advances and applications of methods for the identification of relevant epidemiological, toxicological, and mechanistic scientific data to be relied upon in chemical assessments. Sessions involved a number of scientific experts and were part of a three-part workshop series supporting implementation of a systematic review process within the EPA’s IRIS program.

Dr. Wikoff has extensive expertise in the area of systematic reviews, particularly with regards to the assessment of adverse effects potentially associated with consumption of caffeine.  Dr. Wikoff has also registered several systematic review protocols, which can be viewed here.

IARC Classifies Red Meat as a Probably Carcinogenic to Humans and Processed Meat as Carcinogenic to Humans

An International Agency for Research on Cancer’s (IARC) Working Group of 22 experts met October 6-13, 2015, in Lyon, France, to discuss the potential carcinogenicity of red meat (e.g., beef, veal, lamb) and processed meat (e.g., hot dogs, ham, sausage)..

Based on its evaluation, the Working Group classified the consumption of red meat as probably carcinogenic to humans (Group 2A) based on limited evidence in humans and strong mechanistic evidence to support a carcinogenic effect. The Working Group reported the main effect was for colorectal cancer but associations were also seen for pancreatic and prostate cancers. IARC stated limited evidence indicates that “a positive association has been observed between exposure to the agent and cancer but that other explanations for the observations (technically termed chance, bias, or confounding) could not be ruled out.”

Processed meat was classified as being carcinogenic to humans (Group 1) based on sufficient evidence in humans that consumption of processed meat causes colorectal cancer. IARC stated experts concluded the risk of colorectal cancer increases by 18% for each 50 grams (or 1.8 ounces) of processed meat consumed daily. An association with stomach cancer was reported for processed meat, but the evidence was not determined to be conclusive.

Regarding the question of what might be responsible for the reported increase in cancer, IARC states, “…it is not yet fully understood how cancer risk is increased by red meat or processed meat.”  The Working Group also stated that while high temperature cooking methods create compounds that may contribute to risk, “…their role is not yet fully understood,” and “there were not enough data for the IARC Working Group to reach a conclusion about whether the way meat is cooked affects the risk of cancer.”  IARC reported that there is inadequate evidence in experimental animals for carcinogenicity for both red meat and processed meat.

IARC will publish the results of the meeting and its findings in Volume 114, Consumption of Red Meat and Processed Meat. A copy of the article on summary of the findings of the meeting published in the October 26, 2015, issue of Lancet Oncology can be found here.

The IARC press release on its findings for red meat and processed meat can be downloaded here

A copy of the IARC Q&A on the carcinogenicity of red meat and processed meat can be downloaded here

ToxStrategies will be attending the Society of Environmental Toxicology and Chemistry (SETAC) North America’s 36^th Annual Meeting in Salt Lake City, Utah next week (November 1-5, 2015). Alea T. Goodmanson and Kirby H. Tyndall are looking forward to seeing some familiar faces and meeting new people. Stop by and visit them at booth #1001!

For more information on the scientific program or other meeting details, please click here.

The Joint Research Centre (JRC) recently published a technical report reviewing recent developments in mixtures assessment methodologies and their applications in the hazard assessments.

The report reviews the use of emerging technologies, including in vitro assays, omics approaches, SAR and QSAR modeling, read-across, and PBTK modeling in evaluating mixtures toxicity. Survey results are also included detailing how experts use these novel methodologies to evaluate chemical mixtures. The report concludes that there is high potential for the application of these new methodologies; however, more guidance and standardization on the use of these tools in hazard assessment of mixtures is still needed.

For a copy of the JRC’s technical report on scientific methodologies for the assessment of combined effects of chemicals – a survey and literature review, please click here.

The National Toxicology Program (NTC) recently released the Handbook for Preparing Report on Carcinogens (RoC) Mongraphs, a science-based public health document.

The Handbook provides instructions for conducting the cancer hazard evaluation and preparing the RoC monographs. It is a living document and may be refined to incorporate new systematic review tools, to harmonize with systematic review methods used by other scientists, and from lessons learned from conducting cancer hazard evaluations on candidate substances with more diverse databases.

For a full copy of NTP’s Handbook for Preparing RoC Monographs, please click here.