Menzie CA, Ziccardi LM, Lowney YW, Fairbrother A, Shock SS, Tsuji JS, Hamai D, Proctor D, et al. 2009. Importance of considering the framework principles in risk assessment for metals. Environ Sci Technol 43(22):8478-8482.
The chemical diversity of metals and metalloids, with radically different toxicities even across oxidation states, means that assessment of risk to humans or ecological receptors can involve complex considerations. A recent “Framework” to draw together commonalities in metal/metalloid toxicity outlines generalized considerations. In this Viewpoint, Menzie et al., using exemplary species, explain their approach to aid regulation of metals in the environment in this new framing.