Publications

Doepker C, Franke K, Myers E, Goldberger JJ, Lieberman HR, O’Brien C, Peck J, Tenenbein M, Weaver C, Wikoff D. 2018. Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Nutrients 10:1536, doi: 10.3390/nu10101536.

Wikoff DS, Rager JE, Harvey S, Haws L, Chappell G, Borghoff S. Development and refinement of a framework for quantitative consideration of study quality and relevance in the evaluation of mechanistic data based on Key Characteristics of Carcinogens. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.

Wikoff DS, Welsh BT, Henderson R, Brorby G, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brien C, Doepker C. Application of systematic reviews in the evaluation of caffeine safety: Potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.

Bichteler A, Wikoff DS, Loko F, Harris MA. 2017. Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data. Environ Int 105:112-125; doi: 10.1016/j.envint.2017.05.003.

Hoffmann S, de Vries RB, Stephens ML, Beck NB, Dirven HAAM, Fowle III JR, Goodman JE, Hartung T, Kimber I, Lalu MM, Thayer K, Whaley P, Wikoff D, Tsaioun K. 2017. A primer on systematic reviews in toxicology. Arch Toxicol DOI: 10.1007/s00204-017-1980-3.

Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brian C, Peck J, Tenebein M, Weaver C, Harvey S, Urban J, Doepker C. 2017. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 109(Pt1):585-648. https://doi.org/10.1016/j.fct.2017.04.002.

Wikoff DS, Rager J, Harvey S, Haws L, Chappell G, Borghoff S. 2017. Framework for quantitative consideration of study quality and relevance in the systematic evaluation of mechanistic data per the Ten Key Characteristics of Carcinogens. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

Doepker D, Tyndall K, Lane R, Wikoff D, Thompson C, Harvey S, Schmitt D. 2017. A proposed ADI for nitrate. Poster presented at Society of Toxicology Annual Meeting, March 16, Baltimore, MD.

Chappell G, Welsh B, Harvey S, Harris M, Wikoff D. Validation and application of a text mining tool in the identification and categorization of mechanistic data: A case study in improving problem formulation of carcinogenicity assessments. Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.

Suh M, Harvey S, Wikoff D, Mittal L, Ring C, Goodmanson A, Proctor D. Meta-analysis of hexavalent chromium and stomach cancer. Poster presented at Society of Toxicology 56th Annual Meeting, March 13, Baltimore, MD, March 2017.

Wikoff D, Suh M, Harvey S, Proctor D, Beretvas T, Goodman M, Lipworth L. 2016. Systematic review and meta-analysis of occupational exposure to Cr(VI) and stomach cancer. PROSPERO 2016:CRD42016051625 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016051625

Wikoff D, Borghoff S, Rager J, Harvey S, Haws L. 2016. A systematic review of the mechanistic evidence of tetrabromobisphenol TBBPA as a human carcinogen according to the ten key characteristics of carcinogens (TKCC) identified by Smith et al. (2016). PROSPERO 2016:CRD42016046429 Available from:  http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016046429

Thompson CM, Suh M, Mittal L, Wikoff D, Welsh B, Proctor DM. 2016. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul Toxicol Pharmacol 80:60-70.

Wikoff D, Borghoff SJ, Rager JE, Haws LC. 2016. Human relevance assessment of tetrabromobisphenol-A (TBBPA) induced uterine adenocarcinomas: Mode of action dependent on high dose molecular initiating event (MIE). Presented in the “Flame Retardants” session at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Borghoff SJ,  Wikoff D, Rager JE, Haws LC. 2016. Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

Wikoff DS, Britt JK.  2016. The role of systematic review in the practice of toxicology and risk assessment – An appreciation for the primary tool in evidence-based approaches.  Toxicology: Open Access 2(110):1-4. 

Wikoff DS, Rager JE, Haws LC, Borghoff SJ. 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77:143-159. doi: 10.1016/j.yrtph.2016.01.018

Borghoff SJ, Wikoff D, Harvey S, Haws L. 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi:10.1016/j.toxrep.2016.01.007

Wikoff D, Doepker C, Welsh B, Urban J, Henderson R, Britt J, Harvey S, Goldberger J, Myers E, O’Brien C, Peck J, Lieberman H, Weaver C, Tenebein M. 2015. Systematic review of the adverse bone and calcium balance effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026609 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015026609 (Systematic Review Protocol Registration)

Wikoff D, Doepker C, Welsh B, Urban J, Henderson R, Brorby G, Britt J, Harvey S, Goldberger J, Myers E, O’Brien C, Peck J, Lieberman H, Weaver C, Tenebein M. 2015. Systematic review of the adverse cardiovascular effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026673 Available from http://www.crd.york.ac.uk/PROSPERO/display_record. asp?ID=CRD42015026673 (Systematic Review Protocol Registration)