Publication Topic

Andersen ME, Gentry PR, Swenberg JA, Mundt KA, White KW, Thompson C, Bus J, Sherman JH, Greim H, Bolt H, Marsh GM, Checkoway H, Coggon D, Clewell HJ. 2019. Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop. Regul Toxicol Pharmacol 106(Aug):210–223; doi: 10.1016/j.yrtph.2019.04.015.

Clewell RA, Thompson CM, Clewell HJ. 2019. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment. Chem Biol Interact 301(March):112–127; doi: 10.1016/j.cbi.2019.01.025.

Chappell G, Rager J, Wolf J, Babic M, Leblanc, Ring C, Harris MA, Thompson CM. 2019. Comparison of gene expression responses in the small intestine of mice following exposure to three carcinogens using the S1500+ gene set informs a potential common adverse outcome pathway. Toxicol Pathol 47(7):851-864; doi: 10.1177/0192623319873.

van de Ligt J, Borghoff SJ, Yoon M, Ferguson LJ, DeMaio W, McClanahan RH. 2019. Nondetectable or minimal detectable residue levels of N-(n-butyl) thiophosphoric triamide in bovine tissues and milk from a 28-d NBPT dosing study. Translat An Sci 3(4)1606-1616; doi: 10.1093/tas/txz153.

Mease K. Managing immunogenicity in the absence of an ADA assay is no monkey business (case study). Presentation at 25^th annual Charles River Biotech Symposium, Carlsbad, CA, September 2019.

Thompson CM, Fitch SE, Ring C, Rish W, Cullen JM, Haws LC. 2019. Development of an oral reference dose for the perfluorinated compound GenX. J Appl Toxicol 39:1267–1282.

Yoon M, Ring C, Van Landingham CB, Suh M, Song G, Antonijevic T, Gentry PR, Taylor MD, Keen AM, Andersen ME, Clewell JH. 2019. Assessing children’s exposure to manganese in drinking water using a PBPK model. Toxicol Appl Pharmacol 380(Oct 1):114695; doi: 10.1016/j.taap.2019.114695.

Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh JH, Auerbach SS, Rager JE. 2019. Identifying attributes that influence in vitro-to-in vivo concordance by comparing Tox21 bioactivity versus DrugMatrix transcriptomic responses across 130 chemicals. Toxicol Sci 167(1):157–171; doi: 10.1093/toxsci/kfy220. PMID: 30202884.

Unice KM, Weeber MP, Abramson MM, Reid RCD, van Gils JAG, Markus AA, Vethaak AD, Panko JM. 2019. Characterizing export of land-based microplastics to the estuary – Part II: Sensitivity analysis of an integrated geospatial microplastic transport modeling assessment of tire and road wear particles. Sci Tot Environ 646(Jan 1):1650–1659; doi: 10.1016/j.scitotenv.2018.08.301.

Unice KM, Weeber MP, Abramson MM, Reid RCD, van Gils JAG, Markus AA, Vethaak AD, Panko JM. 2019. Characterizing export of land-based microplastics to the estuary — Part I: Application of integrated geospatial microplastic transport models to assess tire and road wear particles in the Seine watershed. Sci Tot Environ 646(Jan 1):1639–1649; doi: 10.1016/j.scitotenv.2018.07.368.

Panko JM, Hitchcock KM, Fuller GW, Green D. 2019. Evaluation of tire wear contribution to PM2.5 in urban environments. Atmosph 10(2):99; doi: 10.3390/atmos10020099.

Wikoff D, Haws L, Ring C, Budinsky R. 2019. Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. J Appl Toxicol 39(9):1293-1310; doi: 10.1002/jat.3814.

Beckett EM, Cyrs WD, Abelmann A, Monnot AD, Gaffney SH, Finley BL. 2019. Derivation of an occupational exposure limit for diacetyl using dose-response data from chronic animal inhalation exposure study. J Appl Toxicol 39(5):688–701.

Wikoff D, Erranguntla N, Lewis J, Foreman J. A fit-for-purpose framework for use of systematic methods in risk assessment. Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Urban J, Wikoff D, Haws L. Three-tiered approach to integrating evidence streams assessing gestational trichloroethylene exposure and congenital heart defects (TCE-CHD). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine. Washington, DC, June 2019.

Borghoff S, Fitch S, Britt J, Franke K, Wikoff D. Application of the EFSA/ECHA endocrine disruption guidance as a framework for evidence integration in a weight-of-evidence (WoE) analysis for oxybenzone (BP-3). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Kreider ML, Hynds ES, Panko JM. Evaluation of tire and road wear particles (TRWP) in air in Delhi, India. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Heintz MM, Kumar R, Rutledge M, Baldwin WS. 2019. Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis. J Nutr Biochem 70(August):125–137; doi: 10.1016/j.jnutbio.2019.05.004.

Heintz MM, Kumar R, Baldwin WS. Cyp2b-null male mice are susceptible to high-fat diet-induced obesity due to changes in PUFA metabolism and response to hepatic lipids as measured by RNAseq. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.

Olack E, Heintz MM, Baldwin WS. Human CYP2B6 is an anti-obesity enzyme involved in unsaturated fatty acid metabolism. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.