Publications

Choksi N, McMillan D, Schmitt D, Doepker C, Henderson RG. 2026. Demonstration of safety for rice bran wax and sunflower wax based on bridging to other naturally derived waxes used in food. Regul Toxicol Pharmacol 165(Feb):105990; doi: 10.1016/j.yrtph.2025.105990. PMID: 41248699.

Crincoli CM, van de Ligt JLG, Eapen AK. Pavel AT, Hanlon PR, Almond-Abbate K, Haugabrooks E,… Henderson RG. 2025. A tool to support food substance safety evaluations in the United States. Regul Toxicol Pharmacol 161(Sept):105838; doi: 10.1016/j.yrtph.2025.105838. PMID: 40324559.

Oller A, Barroso J, Prieto P, Verougstraete V, Heim K, Henderson R. 2024. Response to letter to editors submitted by PE Rasmussen, P Huntsman, TM Singer, MN Jacobs, and CC Trevithick-Sutton (Aug 2024). Regul Toxicol Pharmacol 154(Dec):105740; doi: 10.1016/j.yrtph.2024.105740. PMID: 39557211.

Henderson RG, Vincent M, Rivera BN, Bonn-Miller MO, Doepker C. 2023. Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use. Regul Toxicol Pharmacol 144(Oct):105482; doi: 10.1016/j.yrtph.2023.105482. PMID: 37634699.

Kulpa J, Lefever TW, Trexler KR, Henderson RG, MacNair L, Toth ML, Vanapalli SA, Rahman M, Gupta S, Bonn-Miller MO. 2023. Toxicity of cannabigerol: Examination of long-term toxicity and lifespan in Caenorhabditis elegans and 14-day study in Sprague Dawley rats. Cannabis Cannabinoid Res 8(S1):S62–S70; doi: 10.1089/can.2023.0035.

Kulpa J, Henderson RG, Schwotzer D, Dye W, Trexler KR, McDonald J, Lefever TW, Bonn-Miller MO. 2023. Toxicological evaluation and pain assessment of four minor cannabinoids following 14-day oral administration in rats. Cannabis Cannabinoid Res 8(S1):S25–S41 doi: 10.1089/can.2023.0049. PMID: 37721989.

Henderson RG, Franke KS, Payne LE, Franzen A. 2023. Cannabidiol safety data: A systematic mapping study. Cannabis Cannabinoid Res 8(1):34–40; doi: 10.1089/can.2022.0100. PMID: 36251454.

Henderson RG, Lefever TW, Heintz MM, Trexler KR, Borghoff SJ, Bonn-Miller MO. 2023. Oral toxicity evaluation of cannabidiol. Food Chem Toxicol 176(June):113786; doi: 10.1016/j.fct.2023.113778. PMID: 37105391.

Henderson RG, Welsh BT, Rogers JM, Borghoff SJ, Trexler KR, Bonn-Miller MO, Lefever TW. 2023. Reproductive and developmental toxicity evaluation of cannabidiol. Food Chem Toxicol 176(June):113786; doi: 10.1016/j.fct.2023.113786. PMID: 37105390.

Henderson RG, Welsh BT, Trexler KR, Bonn-Miller MO, Lefever TW. 2023. Genotoxicity evaluation of cannabidiol. Regul Toxicol Pharmacol 142(August):105425; doi: 10.1016/j.yrtph.2023.105425. PMID: 37271419.

Rivera BN, Svetlik A, Klaren WD, Wikoff DS, Henderson RG. Scoping review of the immunomodulatory effects of cannabidiol: Effects within T cells. Poster presented at Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.

Lefever TW, Schwotzer D, Bonn-Miller MO, McDonald J, Henderson RG, Trexler KR. Novel data update on oral toxicity of phytocannabinoids in rats after 14-days repeated dosing. Carolina Cannabinoid Collaborative (CCC) Conference, Greenville, NC, November 2022.

Lefever TW, Trexler KR, Henderson RG, Bonn-Miller MO. Pre-clinical evaluation of cannabidiol toxicity in rats. Poster at the 32nd Annual International Cannabinoid Research Society Symposium on the Cannabinoids, Galway, Ireland, June 2022.

Henderson RG, Nguyen H. 2022. Pathways to the US supplement market: New dietary ingredient notification and Generally Recognized as Safe determination. Chapter 19 in: Ruthsatz M, Wong AW (eds), Nutrition, Health, and Disease: Regulatory Policy Matters. Regulatory Affairs Professionals Society, E-Book, 427 pp., ISBN: 978-1-947493-82-7.

Franke K, Payne L, Franzen A, Wikoff D, Henderson R. 2021. Cannabidiol literature scoping review protocol. Center for Open Science, OSFHOME (May 20).

Henderson RG, Franzen A, Franke K, Payne L, Schmitt D, Wikoff D. Creating a literature database for cannabidiol (CBD): Systematic evidence mapping. Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.

Henderson RG, Doepker C, Lopez JG. Safety evaluation of L-theanine administered via hard chew to dogs. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Verougstraete V, Henderson R, Mackie C, Newson T, Oller A. 2018. Human health (toxicity) assessment of complex inorganic materials. In: Verougstraete V (ed), Risk Management of Complex Inorganic Materials. Elsevier Inc. ISBN 978-0-12-811063-8.

Wikoff DS, Welsh BT, Henderson R, Brorby G, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brien C, Doepker C. Application of systematic reviews in the evaluation of caffeine safety: Potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Society of Risk Analysis Annual Meeting, Arlington, VA, December 2017.

Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J,…, Harvey S, Urban J, Doepker C. 2017. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 109(Pt1):585-648; doi: 10.1016/j.fct.2017.04.002. PMID: 28438661.