Publications

Diemar MG, Giusti A, Michel-Caillet C, Leme DM, Wikoff D, Bloch D, Sass J, Beekmann K, et al. 2025. How to organize a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18-20 June 2024. Arch Toxicol; doi: 10.1007/s00204-025-04064-6. Online ahead of print May 15, 2025. PMID: 40372420.

Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C. 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 115490; doi: 10.1016/j.fct.2025.115490. Online ahead of print May 2, 2025. PMID: 40320068.

Wikoff D. An introduction to evidence integration. Workshop Session, Abstract 1333, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Wikoff D, Fitch S, Vincent M, Southall MD, Atillasoy E, Weinstein RD, Ejaz SD, Rhoden JD, Choksi N. Biological plausibility assessment of acetaminophen and occurrence of developmental neurological outcomes in humans. Abstract 4768, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025. (Honored as one of the Risk Assessment Specialty Section’s Top 10 Abstracts).

Fitch S, Wikoff D, Foreman J, Buerger A, Haws L, Palmero C. Assessment of relative potency factors for six phthalates. Abstract 4235, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Wikoff DS, Vincent MJ, Heintz MM, Pastula ST, Reichert H, Klaren WD, Haws LC. 2025. Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response. Toxicol Sci 204(1):96-115; doi: 10.1093/toxsci/kfae152. PMID: 39792025.

Wikoff D. Use cases of strategic application of ML/AI in the risk assessment process. Toxicology Forum 2025 Winter Meeting, Raleigh, NC, February 2025.

Wikoff D. Pragmatic solutions for better using evidence-based methods to integrate observational data in food safety assessments. Toxicology Forum 2025 Winter Meeting, Raleigh, NC, February 2025.

Kennedy SB, Heintz MM, Klaren WD, Wikoff DS, Haws LC, Fitch SE. 2025. An integrated ecotoxicological study reliability framework for use in toxicity value development. Environ Tox Chem 44(4):1142-1153; doi: 10.1093/etojnl/vgaf030. PMID: 39873747.

Mattes RD, Rivera BN, Rutigliani GR, Rogers S, Mendoza ID, Wang L, Beckemeier K, Wikoff D. 2024. A review of low- and no-calorie sweetener safety and weight management efficacy. Nutrition Today 59(6):261-288; doi: 10.1097/NT.0000000000000723.

Mathisen GH, Bearth A, Jones LB, Hoffmann S, Vist GE, Ames HM,… Wikoff D, Wright F, Whaley P. 2024. Editorial: Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Arch Toxicol 98(8):2299-2308; doi: 10.1007/s00204-024-03802-6. PMID: 38877155.

Vincent MJ, Fitch S, Bylsma L, Thompson C, Rogers S, Britt J, Wikoff D. 2024. Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility. Toxicol Sci 199(2):172–193; doi: 10.1093/toxsci/kfae039. PMID: 38547404.

Wikoff D, Fitch S. 2024. Evidence‐based methods in toxicology: Systematic review and systematic evidence mapping. Chapter 32 in: Paustenbach DJ (ed), Human and Ecological Risk Assessment: Theory and Practice, Third Edition, pp. 1133–1148. Wiley, ISBN: 978-1-119-74296-8.

Mihalchik AL, Choksi NY, Roe AL, Wisser M, Whitaker K, Seibert D, Deore M, Pavlick L, Wikoff DS. 2024. Safety evaluation of 8 drug degradants present in over-the-counter cough and cold medications. Regul Toxicol Pharmacol 149(May):105621; doi: 10.1016/j.yrtph.2024.105621. PMID: 38608922.

Fitch S, Ellis-Hutchings R, Rogers J, Marty S, Rushton E,… Wikoff D. Study quality evaluation of literature reporting plastic microparticle exposure against reproductive and developmental toxicity endpoints. Abstract 5159, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.

Vincent M, Fitch S, Bylsma L, Thompson C, Rogers S, Britt J, Wikoff D. Integration of toxicological and epidemiological information to evaluate biological plausibility and causality of associations between inhaled formaldehyde (FA) and lymphohematopoietic (LHP) cancers. Abstract 5157, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. 

Urban JD, Covington TR, Fitch SE, Wikoff DS. Dioxin-like compounds in soils: A pilot survey updating background soil TEQ. Abstract 5147, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. 

Lynn SG, Lea IA, Urban J, Borghoff SJ, Wikoff D, Fitch S, Perry C, Choksi N, Britt J, Heintz M, Klaren W, et al. Development and application of systematic approach to inventory and interrogate thyroid hormone network information. Abstract 4357, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. 

Thompson CM, Heintz MM, Rogers SI, Fitch SE, Rivera BN, Klaren WD, Vincent MJ, Wikoff DS, Haws LC. Evidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA. Abstract 3654, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.

DeVito, Bokkers B, van Duursen M, van Ede K, Feeley M,… Haws L,… Wikoff D, et al. The 2022 WHO reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls. Abstract 3626, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.