2015 (49 POSTS)
Wirbisky SE , Freeman JL. 2015. Atrazine exposure and reproductive dysfunction through the hypothalamus-pituitary-gonadal (HPG) axis. Toxics 3:414–450; doi: 10.3390/toxics3040414 .
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Topics: atrazine
Madl AK, Kovochich M, Liong M, Finley BL , Paustenbach DJ, Oberdorster G. 2015. Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part II: Importance of physiochemical properties and dose in animal and in vitro studies as a basis for risk assessment. Nanomed: Nanotech Biol Med 11(5):1285–1298; doi: 10.1016/j.nano.2015.02.006 . PMID: 25735266.
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Topics: chromium , cobalt , Metals , risk assessment
James RC, Britt JK , Halmes NC, Guzelian PS. 2015. Evidence-based causation in toxicology: A 10-year retrospective. Hum Exp Toxicol 34(12):1245–1252; doi: 10.1177/0960327115601767 .
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Topics: Toxicology
Wheeler MW, Park R, Bailer A, Whittaker C. 2015. Historical context and recent advances in exposure-response estimation for deriving occupational exposure limits. J Occup Environ Hyg 12(sup1):S7-S17; doi: 10.1080/15459624.2015.1076934 . PMCID: PMC4685605.
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Topics: benchmark dose estimation (BMD) , dose-response , modeling , Occupational , Occupational exposure limits (OELs)
Shah F, Leung L, Barton HA, Will Y, Rodrigues AD, Greene N , Aleo MD. 2015. Setting clinical exposure levels of concern for drug-induced liver injury (DILI) using mechanistic in vitro assays. Toxicol Sci 147(2):500-14; doi: 10.1093/toxsci/kfv152 . PMID: 26206150.
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Topics: drug development , safety assessment
Becker RA, Patlewicz G , Simon T, Rowlands JC, Budinsky RA. 2015. The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Regul Toxicol Pharmacol 73(1):172-190; doi: 10.1016/j.yrtph.2015.06.015 . PMID: 26145830.
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Topics: Adverse outcome pathways (AOPs) , mode of action
Greene N , Pennie W. 2015. Computational toxicology: Friend or foe? Toxicol Res 4(5):1159-1172; doi: 10.1039/c5tx00055f .
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Topics: computational toxicology
Katz AJ, Chia VM, Schoonen WM, Kelsh MA . 2015. Acute lymphoblastic leukemia: An assessment of international incidence, survival, and disease burden. Cancer Causes Control 26(11):1627–1642.
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Topics: Cancer , Epidemiology
Mackay CE, Vivanco SN , Reinhardt TE, McClure S, Vercellone J. 2015. Real-time monitoring and assessment of thermal and toxicological risk associated with fire retardant textiles in a full-size simulation of an engulfment flash fire. Fire Technol 51(5):1167–1193; doi: 10.1007/s10694-015-0456-3 .
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Topics: flame retardants , risk assessment
Wheeler MW , Shao K, Bailer AJ. 2015. Quantile benchmark dose estimation for continuous endpoints. Environmetrics 26(5):363-72; doi: 10.1002/env.2432 .
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Topics: benchmark dose estimation (BMD) , Exposure Assessment , risk analysis , risk assessment
Young RR, Thompson CM , Dinesdurage HR, Elbekai RH, Suh M , Rohr AC, Proctor DM. 2015. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats. Environ Mol Mutagen 56(7):629-636; doi: 10.1002/em.21951 . PMID: 25969955.
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Topics: mode of action
Gaffney SH, Abelmann A, Pierce JS, Glynn ME, Henshaw JL, McCarthy LA, Lotter JT, Liong M, Finley BL . 2015. Naturally occurring diacetyl and 2,3-pentanedione concentrations associated with roasting and grinding unflavored coffee beans in a commercial setting. Toxicol Rep 2(Aug 14):1171–1181; doi: 10.1016/j.toxrep.2015.08.003 .
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Topics: diacetyl , food additives
Thompson CM , Wolf JC, Elbekai RH, Paranjpe MG, Seiter JM, Chappell MA, Tappero RV, Suh M , Proctor DM , Bichteler A, Haws LC , Harris MA. 2015. Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron x-ray fluorescence microscopy. Mut Res 789–790:61–66; doi: 10.1016/j.mrgentox.2015.05.004 .
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Topics: chromium , microscopy
Steinbach T, Gad-McDonald S, Kruhlak N, Powley M, Greene N . 2015. (Q)SAR: A tool for the toxicologist. Int J Toxicol 34(4):352-4; doi: 10.1177/1091581815584914 . PMID: 25979517.
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Topics: computational toxicology
Greene N , Dobo KL, Kenyon MO, Cheung J, Munzner J, Sobol Z, Sluggett G, Zelesky T, et al. 2015. A practical application of two in silico systems for identification of potentially mutagenic impurities. Regul Toxicol Pharmacol 72(2):335-49; doi: 10.1016/j.yrtph.2015.05.008 . PMID: 25980641.
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Topics: computational toxicology , genotoxicity
Wirbisky SE , Weber GJ, Sepúlveda MS, Xiao C, Cannon JR, Freeman JL. 2015. Developmental origins of neurotransmitter and transcriptome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Toxicology 333:156–167.
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Topics: atrazine
Klaren WD , Gadupudi GS, Wels B, Simmons DL, Olivier AK, Ludewig G, Robertson LW. 2015. Progression of micronutrient alteration and hepatotoxicity following acute exposure to PCB126. Toxicol 338(Dec):1–7; doi: 10.1016/j.tox.2015.09.004 . PMID: 26410179.
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Topics: PCBs
Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. 2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicol 333(2015 July 3):1-13; doi: 10.1016/j.tox.2015.02.003 . PMID: 25797582.
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Topics: Exposure Assessment , mode of action
Gadupudi GS, Klaren WD , Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Superfund Annual Meeting, San Juan, Puerto Rico, 2015.
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Topics: PCBs
Gauthier AM, Fung M, Panko J , Kingsbury T, Perez AL, Hitchcock K, Ferracini T, Sahmel J, Banducci A, Jacobsen M, Abelmann A, Shay E. 2015. Chemical assessment state of the science: Evaluation of 32 decision-support tools used to screen and prioritize chemicals. Integr Environ Assess Manag 11(2):242–255; doi: 10.1002/ieam.1605 .
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