Background: Tick bites may expose individuals to a carbohydrate not found in humans, galactose-alpha-1,3-galactose (alpha-gal), including allergy to mammalian red meat or red meat-derived products presenting 2–6 hours after consuming the product plus positive alpha-gal specific IgE testing that may indicate alpha-gal syndrome (AGS). Anaphylaxis in group O recipients of group B blood products in the absence of other risk factors for allergic transfusion reactions could be transfusion-related alpha-gal syndrome (TRAGS); galactose-alpha-1,3-galactose (Gal-alpha1-3 Galβ1-(3)4GlcNAc-R) is similar to the B blood group antigen (Gal-alpha1-3(Fuc-alpha-1,2)Gal). Objectives: To review scientific and grey literature with no date or language limit to: 1) describe characteristics of all known cases of transfusion-related alpha-gal syndrome (TRAGS) and hypersensitivity reactions to infusions of mammalian red meat-derived medical products besides blood components that may resemble TRAGS; 2) identify studies that explore possible relationships between alpha-gal sensitization and blood group that may be relevant to understanding TRAGS; 3) describe which clinical, laboratory, and epidemiologic parameters used to diagnose AGS food allergy are also appropriate to diagnose TRAGS; and 4) identify which diagnostic assays exist for AGS and how they are used for AGS and/or TRAGS. Methods: Using search strategies peer-reviewed by biomedical librarians we performed a scoping review of literature in five medical databases, charted in Microsoft Excel and Covidence software. Results: Of 11732 studies imported for screening, 3858 duplicates were removed and 7874 papers were screened. Title and abstract screening excluded 7383 papers. Full-text screening excluded 380 papers. Of the included papers, 20/111 (18%) addressed risk for alpha-gal allergy by blood group and 18/111 diagnostics (16%). Conclusion: A comprehensive literature review showed a possible association between alpha-gal allergy and blood group. Further guidance is needed regarding potential clinical implications.