Publications

Borghoff SJ, Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes.  J Appl Toxicol, DOI 10.1002/jat.3412

Wikoff D, Borghoff S, Rager J, Harvey S, Haws L. 2016. A systematic review of the mechanistic evidence of tetrabromobisphenol TBBPA as a human carcinogen according to the ten key characteristics of carcinogens (TKCC) identified by Smith et al. (2016). PROSPERO 2016:CRD42016046429 Available from:  http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016046429

Borghoff SJ. 2016. Organization and review of mechanistic data according to “Ten Key Characteristics of Carcinogens” (TKCC) {Smith et al., 2016}. Presented at the 42^nd Annual Summer Meeting of the Toxicology Forum, July, Salt Lake City, UT.

Wikoff D, Borghoff SJ, Rager JE, Haws LC. 2016. Human relevance assessment of tetrabromobisphenol-A (TBBPA) induced uterine adenocarcinomas: Mode of action dependent on high dose molecular initiating event (MIE). Presented in the “Flame Retardants” session at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Borghoff SJ,  Wikoff D, Rager JE, Haws LC. 2016. Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

DeVito MJ, Borghoff SJ, Zorilla LM, Shockley K, Kissling G,  Travlos G. 2016. The effects of a high fat (HF) diet on male diversity outbred (DO) mice. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Wikoff DS, Rager JE, Haws LC, Borghoff SJ. 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77:143-159. doi: 10.1016/j.yrtph.2016.01.018

Borghoff SJ, Wikoff D, Harvey S, Haws L. 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi:10.1016/j.toxrep.2016.01.007

Hughes BJ, LeBaron MJ, Thomas J, Kan HL, Lynch AM, Borghoff SJ, Green S, Mensing T, Sarang SS, Smulders CJGM. 2015. Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, 2015. San Diego, CA.

Borghoff SJ, Wikoff D, White MC, Thompson C, Haws LC. 2015. Identification of the molecular initiating event (MIE) for TBBPA induced uterine tumors in the framework of an adverse outcome pathway (AOP). Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Wikoff D, White MC, Borghoff SJ, Haws LC. 2015. Evaluation of tetrabromobisphenol A (TBBPA)-induced endocrine-related target gene activity using high-throughput screening data from ToxCast. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Borghoff SJ, Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC.  2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicology 333(2015):1-13.

Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308. doi: 10.1002/jat.3132.

Borghoff SJ, Hard GC, Poet TS, Davis J, Green S, Hughes B, Mensing T, Sarang SS. 2014. Methyl isobutyl ketone (MIBK) induces an exposure-related increase in measures of a2u-globulin (a2u) nephropath in male but not female F344 rats. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Haws LC, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Wikoff D. 2014. Development of non-cancer based toxicity factors and daily dose estimates for TBBPA. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Faber W, Kirkpatrick D, Coder P, Li P, Borghoff S, Banton M. 2014. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regul Toxicol Pharmacol 68:332-342.

Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG and others. 2014. t4 Workshop report — Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. Altex 31(1):63-78.

Wikoff, D., Thompson, C., Perry, C., White, M., Fitzgerald, L., Borghoff, S., Haws, L.C. Development of an oral cancer slope factor and lifetime average daily dose estimates for TBBPA. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, 2014. Phoenix, AZ.