Publication Topic

Wikoff D, Fitch S, Eichenbaum G, Ejaz S, Klaren W, Southall M. Need for fit-for-purpose approaches that integrate dose, mechanism, and context of use with key characteristics when evaluating the carcinogenic potential of widely used therapeutics: A case study of acetaminophen. Abstract 4005, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Pennell ML, Wheeler MW, Auerbach SS. 2024. A hierarchical constrained density regression model for predicting cluster‐level dose‐response. Environmetrics 35(7):e2880; doi: 10.1002/env.2880. PMID: 40894950.

Schaefer H. Introduction: Challenges associated with the use of epidemiologic studies in chemical risk assessments. Abstract 1295, Society of Toxicology 63^rd Annual Meeting, Salt Lake City, UT, 2024.

Schaefer H. Capturing unknowns: Increasing utility of epidemiologic studies as key evidence in chemical risk assessment. Abstract 1294, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, 2024.

Wheeler MW. 2023. An investigation of non-informative priors for Bayesian dose-response modeling. Regul Toxicol Pharmacol 141(June):105389; doi: 10.1016/j.yrtph.2023.105389. PMID: 37061082.

Thompson CM, Proctor DM, Harris MA. 2023. Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data.” Environ Mol Mutagen 64(4):259–260; doi: 10.1002/em.22537. PMID: 36916184.

Wheeler MW, Cortiñas Abrahantes J, Aerts M, Gift JS, Allen Davis J. 2022. Continuous model averaging for benchmark dose analysis: Averaging over distributional forms. Environmetrics 33(5):e2728; doi: 10.1002/env.2728. PMID: 36589902.

Davidson SE, Wheeler MW, Auerbach SS, Sivaganesan S, Medvedovic M. 2022. ALOHA: Aggregated local extrema splines for high-throughput dose–response analysis. Comp Toxicol. 21(Feb):100196; doi: 10.1016/j.comtox.2021.100196. PMID: 35083394.

Lizarraga LE, Patlewicz G, Dean JL II, et al. 2021. Provisional Peer-Reviewed Toxicity Values for 3,4-Toluenediamine (CASRN 496-72-0). Cincinnati (OH): U.S. Environmental Protection Agency; Aug. Available from: https://www.ncbi.nlm.nih.gov/books/NBK584583/

Haber LT, Reichard JF, Henning AK, Dawson P, Chinthraja RS, Sindher SB, Long A, Vincent MJ, et al. 2021. Bayesian hierarchical evaluation of dose-response for peanut allergy in clinical trial screening. Food Chem Toxicol 151(May):112125; doi: 10.1016/j.fct.2021.112125. PMID: 33722597.

Houben GF, Baumert JL, Blom WM, Kruizinga AG, Meima MY, Remington BC, Wheeler MW, Westerhout J, Taylor SL. 2020. Full range of population eliciting dose values for 14 priority allergenic foods and recommendations for use in risk characterization. Food Chem Toxicol 146(Dec)111831; doi: 10.1016/j.fct.2020.111831. PMID: 33166672.

Aerts M, Wheeler MW, Abrahantes JC. 2020. An extended and unified modeling framework for benchmark dose estimation for both continuous and binary data. Environmetrics 31(7):e2630; doi: 10.1002/env.2630. PMID: 36052215.

Wheeler MW, Blessinger T, Shao K, Allen BC, Olszyk L, Davis JA, Gift JS. 2020. Quantitative risk assessment: Developing a Bayesian approach to dichotomous dose–response uncertainty. Risk Anal 40(9):1706-22; doi: 10.1111/risa.13537. PMID: 32602232.

Beckett EM, Cyrs WD, Abelmann A, Monnot AD, Gaffney SH, Finley BL. 2019. Derivation of an occupational exposure limit for diacetyl using dose-response data from chronic animal inhalation exposure study. J Appl Toxicol 39(5):688–701; doi: 10.1002/jat.3757. PMID: 30620996.

Wheeler MW, Piegorsch WW, Bailer AJ. 2019. Quantal risk assessment database: A database for exploring patterns in quantal dose‐response data in risk assessment and its application to develop priors for Bayesian dose‐response analysis. Risk Anal 39(3):616-29; doi: 10.1111/risa.13218. PMID: 30368842.

Wheeler MW. 2019. Bayesian additive adaptive basis tensor product models for modeling high dimensional surfaces: An application to high-throughput toxicity testing. Biometrics 75(1):193-201; doi: 10.1111/biom.12942. PMID: 30081432.

Vincent MJ, Allen BA, Palacios OM, Haber LT, Maki KC. 2019. Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol. Am J Clin Nutr 109(1):7–16; doi: 10.1093/ajcn/nqy273. PMID: 30596814.

Thompson C, Kirman C, Suh M, Proctor D, Haws L, Harris M, Hays S. Risk assessment of oral exposure to Cr(VI): Integration of mode of action, pharmacokinetics, and dose-response modeling. Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.

Mease K, Kimzey A, Lansita J. Failed dose formulation analysis during a GLP study — Now what? Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.

Wheeler MW, Park R, Bailer A, Whittaker C. 2015. Historical context and recent advances in exposure-response estimation for deriving occupational exposure limits. J Occup Environ Hyg 12(sup1):S7-S17; doi: 10.1080/15459624.2015.1076934. PMCID: PMC4685605.