2020 (62 POSTS)
Fryzek J, Bylsma L , Mease K , Movva N , Welsh BT, Wood M . 2020. Critical insights into nonclinical toxicology and real-world evidence essential for a successful rare disease product launch. EpidStrategies, Inc. White Paper .
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Publication: White paper
Mullen KR, Rivera BN , Tidwell AG, Ivanek R, Anderson KA, Ainsworth DM. 2020. Environmental surveillance and adverse neonatal health outcomes in foals born near unconventional natural gas development activity. Sci Tot Environ 731(Aug 20):138497; doi: 10.1016/j.scitotenv.2020.138497 . PMID: 32434096.
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Publication: Manuscripts
Thompson CM , Donahue DA, Hobbs C, Costecalde Y, Franzen A , Suh M , Proctor DM , Harris MA. 2020. Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice. Regul Toxicol Pharmacol 116:104729; doi: 10.1016/j.yrtph.2020.104729 .
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Publication: Manuscripts
Lafranconi M, Budinsky R, Corey L, Haws L , Klapacz J, Chappell G, Golden R. Exposure to 1,4-dioxane above the metabolic saturation threshold induces a mitogenic key element in the mouse liver cancer mode of action. Abstract #1505. Society of Toxicology 59th Annual Meeting, Virtual, 2020.
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Publication: Abstracts and Presentations
East A , Price P, Dawson D, Glen G, Dionisio K, Isaacs K, Hubal EC, Vallero D. The Residential Population Generator (RPGen): Parameterization of residential, demographic, and physiological data to model intraindividual exposure, dose, and risk (presentation). Poster presented at Society of Environmental Toxicology and Chemistry North America 41st Annual Meeting, virtual conference, 2020. doi: 10.23645/epacomptox.13476864 .
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Publication: Abstracts and Presentations
Elbeddini A, Hooda N , Gazarin M, Webster P, McMillan J. 2020. Irinotecan-associated dysarthria in patients with pancreatic cancer: A single site experience. Am J Case Rep 21:e924058; doi: 10.12659/AJCR.924058 . PMID: 32594093.
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Publication: Manuscripts
Chesney A, Welsh B, Kimzey A , Lansita J. The process and challenges of deriving exposure-based limits for toxicological risk assessment for components and impurities present in cell therapy products with case studies. Poster for Society of Toxicology , Virtual Annual Meeting, 2020.
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Publication: Abstracts and Presentations
Bell S, Abedini J, Ceger P, Chang X, Cook B, Karmaus AL, Lea I , Mansouri K, et al. 2020. An integrated chemical environment with tools for chemical safety testing. Toxicol in Vitro 67(Sept):104916; doi: 10.1016/j.tiv.2020.104916 .
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Publication: Manuscripts
Zorn KM, Foil DH, Russo DP, Clark AM, Hillwalker W, Feifarek D, Jones F, Klaren W , Brinkman A, Ekins S. Generation of machine-learning models to anticipate endocrine disruption. Society of Toxicology 59th Annual Meeting, virtual, 2020.
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Publication: Abstracts and Presentations
Brinkman AM, Klaren WD , Feifarek DJ, Hillwalker W, Jones F, Zorn KM, Ekins S. Use of a weighted scheme for the interpretation and contextualization of in vitro and in silico-derived estrogenic endpoints. Society of Toxicology 59th Annual Meeting, virtual, 2020.
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Publication: Abstracts and Presentations
Chappell GA, Thompson CM , Wolf JC, Cullen JM, Klaunig JE, Haws LC . 2020. Assessment of the mode of action underlying the effects of GenX in mouse liver and implications for assessing human health risks. Toxicol Pathol 48(3):494–508; doi: 10.1177/0192623320905803 . PMID: 32138627.
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Publication: Manuscripts
Urban JD , Wikoff DS , Chappell GA, Harris C, Haws LC . 2020. Systematic evaluation of mechanistic data in assessing in utero exposures to trichloroethylene and development of congenital heart defects. Toxicology 436(30 April):152427; doi: 10.1016/j.tox.2020.152427 . PMID: 32145346.
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Publication: Manuscripts
Buerger AN , Dillon DT, Schmidt J, Yang T, Zubcevic J, Martyniuk CJ, et al. 2020. Gastrointestinal dysbiosis following diethylhexyl phthalate exposure in zebrafish (Danio rerio ): Altered microbial diversity, functionality and network connectivity. Environ Pollut 265(Pt B):114496 .
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Publication: Manuscripts
Grimm FA, Klaren WD , Li X, Lehmler HJ, Karmakar M, Robertson LW, Chiu WA. Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Persp 128(7):77008; doi: 10.1289/EHP7030 . PMID: 32701041.
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Publication: Manuscripts
Zorn KM, Foil DH, Lane TR, Russo DP, Hillwalker W, Feifarek DJ, Jones F, Klaren WD , Brinkman AM, Ekins S. 2020. Machine learning models for estrogen receptor bioactivity and endocrine disruption prediction. Environ Sci Technol 54(19):12202–12213; doi: 10.1021/acs.est.0c03982 . PMID: 32857505.
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Publication: Manuscripts
House JS, Grimm FA, Klaren WD , Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, Ketelsegers HB, Gant TW, Wright FA, Rusyn I. 2020. Grouping of UVCB substances with new approach methodologies (NAMs) data. ALTEX 38(1):123–137; doi: 10.14573/altex.2006262 .
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Publication: Manuscripts
Zorn KM, Foil DH, Lane TR, Hillwalker W, Feifarek DJ, Jones F, Klaren WD , Brinkman AM, Ekins S. 2020. Comparing machine learning models for aromatase (P450 19A1). Environ Sci Technol 54(23):15546–15555; doi: 10.1021/acs.est.0c05771 . PMID: 33207874.
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Publication: Manuscripts
Zorn KM, Foil DH, Lane TR, Hillwalker W, Feifarek DJ, Jones F, Klaren WD , Brinkman AM, Ekins S. 2020. Comparison of machine learning models for the androgen receptor. Environ Sci Technol 54(21):13690–13700; doi: 10.1021/acs.est.0c03984 . PMID: 33085465.
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Publication: Manuscripts
Heintz MM, McRee, R, Kumar, R, Baldwin, WS. 2020. Gender differences in diet-induced steatotic disease in Cyp2b-null mice. PLoS ONE 15(3):e0229896; doi: 10.1371/journal.pone.0229896 .
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Publication: Manuscripts
Choksi N , Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, et al. Developing a defined approach for eye irritation testing. Poster presented at Society of Toxicology 59th Annual Meeting, Virtual, March 2020.
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