2016 (63 POSTS)
LaPlaca SB , Scott GI. Assessing potential endocrine disruption in largemouth bass from a PCB-contaminated reservoir in South Carolina. Poster presentation at the 37th annual meeting of the Society of Environmental Toxicology and Chemistry, North America Chapter, Orlando, FL, November 2016.
Publication: Abstracts and Presentations
Theunissen PT, Beken S, Beyer BK, Breslin WJ, Cappon GD , Chen C, et al. 2016. Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects. Crit Rev Toxicol 46:900–910, DOI: 10.1080/10408444.2016.1224807, open access online .
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Publication: Manuscripts
Borghoff SJ , Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes. J Appl Toxicol , DOI 10.1002/jat.3412
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Publication: Manuscripts
Ulrich, K. Adversity and risk assessment of respiratory tract findings — A regulatory perspective. Presentation to the 31st Annual Meeting of the British Society of Toxicological Pathology (BSTP) — Association of Inhalation Toxicologists Joint Conference, Alderley Edge, Cheshire, UK, 2016.
Publication: Abstracts and Presentations
Wirbisky SE , Sepúlveda MS, Weber GJ, Jannasch AS, Horzmann KA, Freeman JL. 2016. Embryonic atrazine exposure elicits alterations in genes associated with neuroendocrine function in adult male zebrafish. Toxicol Sci 153:149–164.
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Publication: Manuscripts
Bi P, Yue F, Karki A, Castro B, Wirbisky SE , Wang C, … Kuang, S. 2016. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med 213(10):2019–2037.
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Publication: Manuscripts
Bi P, Yue F, Sato Y, Wirbisky S , Liu W, Shan T, Wen Y, Zhou D, Freeman J, Kuang S. 2016. Stage-specific effects of notch activation during skeletal myogenesis. Elife 5:e17355.
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Publication: Manuscripts
Schmitt G, Ridings J, De Schaepdrijver L, van Doesum-Wolters C, Cappon GD , Hartmann A. 2016. Nonclinical safety considerations for the development of pediatric-first drugs: An industry view. Therapeut Innov Regul Sci 50(5):632–638, DOI:10.1177/2168479016642813 , online article .
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Publication: Manuscripts
Mackay CE, Vivanco SN , Yeboah G, Vercellone J. 2016. Assessment of dermal hazard from acid burns with fire retardant garments in a full-size simulation of an engulfment flash fire. Burns 42(6):1350–1356.
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Publication: Manuscripts
Klaren WD , Vine D, Vogt S, Robertson LW. Evaluation of the spatial distribution of hepatic metals following PCB126 exposure with x-ray fluorescence microscopy. Society of Toxicology Annual Meeting, New Orleans, La, 2016.
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Publication: Abstracts and Presentations
Gadupudi GS, Klaren WD , Olivier AK, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity. Society of Toxicology, Central States Regional Meeting, Iowa City, IA, 2016. Also presented at NIEHS Obesity Grantee Meeting and 25 Years of Endocrine Disruption Workshop, NIH, Bethesda, MD, 2016.
Publication: Abstracts and Presentations
Klaren WD , Iwata Y, Lebakken CS, Grimm FA, Rusyn I. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. College of Veterinary Medicine Graduate Student and Postdoc Research Symposium, Texas A&M University, 2016.
Publication: Abstracts and Presentations
Panko JM , Benson SM, Kreider ML. Meta-analysis of lung cancer risk related to diesel exposure by occupation and evaluation of exposure response. Abstract #2976. Poster at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.
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Publication: Abstracts and Presentations
Gloekler L, Shay EC, Schmidt N, Haghighat B, Panko JM , Cowan DM, Paustenbach DJ. Flame-retardants in upholstered furnishings: An assessment of health risk and fire-related deaths in the era of California Technical Bulletin (TB-117). Abstract #2669. Poster at Society of Toxicology Annual Meeting , New Orleans, LA, March 13–17, 2016.
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Publication: Abstracts and Presentations
Wang BW, Klaren WD , Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status and MnSOD in the rat. Toxicol Sci 150(1):15–26; doi: 10.1093/toxsci/kfv312 . PMID: 26660635.
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Publication: Manuscripts
Klaren WD , Flor SS, Gibson-Corley KN, Ludewig G, Robertson LW. 2016. Metallothionein’s role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicol Rep 3:21–28. PMID: 26770886.
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Publication: Manuscripts
Klaren WD , Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851–859, PMID: 26967026.
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Publication: Manuscripts
Maskrey JR, Insley A, Hynds ES, Panko JM . 2016. Air monitoring of volatile organic compounds at relevant receptors during hydraulic fracturing operations in Washington County, Pennsylvania. Environ Monit Assess 188(7):1–12, Article 410.
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Publication: Manuscripts
Edmondson SD, Zhu C, Kar NF, Di Salvo J, Nagabukuro H, Sacre-Salem B, Dingley K , et al. 2016. Discovery of vibegron: A potent and selective beta 3 adrenergic receptor agonist for the treatment of overactive bladder. J Med Chem 59(2):609–623; doi: 10.1021/acs.jmedchem.5b01372 . PMID: 26709102.
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Publication: Manuscripts
Zhu C, Kar NF, Li B, Costa M, Dingley KH , Di Salvo J, et al. 2016. Discovery of benzamides as potent human β3 adrenergic receptor agonists. Bioorg Med Chem Lett 26(1):55–59; doi: 10.1016/j.bmcl.2015.11.030 . PMID: 26590100.
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