Chronic fish toxicity data form part of aquatic safety assessments and are mandated under frameworks such as EU REACH. However, traditional in vivo methods rely heavily on animal testing, are resource-intensive, and provide limited information on a few model organisms to protect the environment holistically. In line with the European Commission’s roadmap to phase out animal testing and priorities highlighted by ECHA in their KARC 2025 document, there is growing momentum to implement New Approach Methodologies (NAMs) within Next Generation Risk Assessment (NGRA) for chronic aquatic toxicity. This International Collaboration on Cosmetics Safety (ICCS)-led project aims to address standard information requirements for chronic fish toxicity by evaluating the applicability of NAMs through multiple case studies focused on cosmetic ingredients. Insights from these case studies will be consolidated into an ICCS best practice guidance document to help regulatory and industry safety assessors.
The work is driven by a tiered approach: starting with identification of data gaps and developing solutions to support safety assessments and regulatory registration dossiers (e.g., under REACH), ultimately progressing towards applying environmental Next Generation Risk Assessment (NGRA). The ICCS project is closely aligned with case studies led by other organizations, ensuring cross-fertilisation of approaches and harmonisation of data integration strategies. Together, these efforts aim to inform and shape future OECD Integrated Approaches to Testing and Assessment (IATAs) for chronic aquatic toxicity, promoting global regulatory acceptance of NAM-based frameworks. The poster  provides an initial project overview and outline planned case studies to foster discussion and collaboration with the SETAC community. Ultimately, this work supports regulatory acceptance of NAMs and NGRA, advancing environmental protection anchored on modern science.