Publications : 2025

Franke K, Panko J, Hidding B, DeLee M, Davis CW, Norman J. Development of a database for identification, hazard assessment and risk assessment support for plastic additives in commerce. Abstract 7.04.P-Tu-126, SETAC North America 46th Annual Meeting, Portland, OR, November 2025.

Abstract

Plastics play an essential role in numerous areas of modern life due to their versatility, with characteristics that can be optimized for use in packaging, textiles, electronics, construction materials, and more. However, there is rising global concern about the safety of chemicals used in the manufacturing of plastics (e.g., functional additives) and their potential to be released in the environment. More than 13,000 chemicals associated with plastic materials were identified by the United Nations Environmental Programme (UNEP) in their 2023 report and were screened for hazards and potential risks. However, the approaches used to compile this data were limited to information in the public domain and the data is spread out across multiple publications, making it difficult to interpret and understand plastic additives and the available health and safety information. In response, the user-friendly ICCA Plastic Additives Database was developed to build on this work and make risk related information on uses, hazards, and risk assessments more accessible to facilitate risk communication more equitably to stakeholders and regulators of varying levels of technical expertise. Additions and updates to the database have focused on chemicals known to be used as plastic additives in global commerce using supplemental sources such as US EPA CompTox Chemicals Dashboard, Chemical Abstracts Service (CAS), collaboration with SpecialChem, and a survey of additive manufacturers and producers. The database contains the identification, use and function of plastic additives that are currently confirmed in commerce or that have been in commerce for the past 10 years; physical chemical properties of the chemicals that inform their fate and transport in the environment; hazard classifications of the chemicals according to harmonized determinations; and lists of existing chemical management laws regulating specific additives; and includes an overview page for each substance with quick reference data visualizations for uses, functions, and regions of use; and supporting pages that present detailed data in a manner that is accessible to regulatory agencies and risk assessors around the globe and with varying levels of risk assessment expertise. Additional functionality related to hazard and risk assessment is planned, including the curation of existing hazard and risk assessments for available substances, to aid in screening level risk-based prioritization of these substances. Disclaimer/Disclosure: Database development was funded by the International Council of Chemical Associations.