Publications : 2022

Hulsey A, Cekola P, Henrikson A, Reichert H, Cohen SS, Torres KA. (2022) Growth and Tolerance with an Amino Acid Based Enteral Formula: A Two-year ZĞƚƌŽƐƉĞcƚŝvĞ Study from a Children’s ZĞŚĂbŝůŝƚĂƚŝŽn Hospital. J Clin Nutr Diet Vol.8 No.8:181


Background: This study aimed to identify characteristics of a

medically complex pediatric population that was fed an

amino acid-based formula containing Medium-Chain

Triglycerides (AA-MCT).


Methods: We examined calorie/protein prescription and

intake, formula tolerance, concomitant use of

Gastrointestinal (GI) medications, and growth (weight,

height, Body Mass Index (BMI) z-scores). We reviewed

medical records of children from a Hospital Rehabilitation

Center, identifying those with a history of a tube-fed

formula switch to the AA-MCT (n=23). We recorded

demographic data (age, sex, diagnosis) and compiled

outcomes data (formula intake, tolerance, GI medications,

growth) at key time points over two years (pre-switch, at

switch and post-switch).


Results: At AA-MCT initiation, mean age was 7.5 years and

48% of children had evidence of GI dysfunction. Atopic

dermatitis and food allergies were present in 22%, others

had genetic or metabolic disorders with severe GI

impairment. Following switch to AA-MCT, mean calorie and

protein intake increased, weight and height for age

measures, and BMI z-scores were within expected ranges

for most children. A reduction in GI medications was

observed for some after the switch.


Conclusions: Children with medical complexity switched to

AA-MCT formula demonstrated growth. Formula was well

tolerated, as shown by increased intake of formula,

appropriate growth for age and BMI z-scores up to 1 year



Keywords: Amino acid formula; Pediatric nutrition;

Medically complex child; Enteral nutrition; Gastrointestinal

impairment; Malabsorption; Cow’s milk protein allergy.