Publications : 2020

Saldanha G, Ording AG, Bylsma LC, Darvalics B, Solis D, Tang JY, Sorensen HT, Fryzek J. 2020. High frequency basal cell carcinoma (BCC) in Danish patients: Prevalence and consistency. J Eur Acad Dermatol Venereol Apr 20 doi: 10.1111/jdv.16512 (Epub ahead of print).


A very small subset of basal cell carcinoma (BCC) patients develop high frequency basal cell carcinoma (HF-BCC), or a high burden of continuous BCCs. One definition of HF-BCC is 9 or more BCCs diagnosed over a three-year period. Some of these patients have the rare Gorlin Syndrome, generally resulting from a mutation in the PTCH1 gene. However, limited studies have been done on the patient population which lacks the non-BCC findings typical for Gorlin Syndrome but nonetheless develops many BCCs. Previous studies have estimated the incidence of BCCs in certain countries; however, none of these studies have reported the prevalence specifically of HF-BCC at the population level.