From the introduction: Technological advances have led to increased utilization of endoscopic endonasal skull base surgery (EESBS) for the management of anterior, middle, and posterior cranial fossa tumors. EESBS has been associated with decreased length of hospitalization, fewer complications and lower health-care costs. Despite these benefits, patients undergoing EESBS incur sinonasal morbidities, leading to unique quality-of-life (QOL) changes as compared with patients undergoing traditional open approaches. The increasing recognition of the importance of QOL after EESBS has led to the creation of a variety of disease-specific QOL instruments. The aim of this work is to comprehsensively synthesize the literature on disease-specific QOL instruments validated for patients undergoing EESBS. We also suggest guidance on use of specific QOL instruments to improve the reporting of EESBS-related QOL outcomes across the literature.