2025 (5 POSTS)
Moyer HL, Vergara L, Stephan C, Sakolish C, Lin HC, Chiu WA, Villenave R, Hewitt P, et al. 2025. Human small intestinal tissue models to assess barrier permeability: Comparative analysis of caco-2 cells, jejunal and duodenal enteroid-derived cells, and EpiIntestinalTM tissues in membrane-based cultures with and without flow. Bioengineering (Basel). 12(8):809; doi: 10.3390/bioengineering12080809 . PMID: 40868322; PMCID: PMC12384003.
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Topics: NAMs
Sakolish C, Moyer H , Barlow N, Roe H, Tsai H, Ford L, Bajaj P, Villenave R, et al. Microphysiological systems as predictive tools for kidney nephrotoxicants: A comparison across four platforms. Abstract 3216, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025 .
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Topics: pharmacokinetics
Moyer H , Vergara L, Sakolish C, Stephan C, Barlow N, Roe H, Hewitt P, Villenave R, Rusyn I. Comparative analysis of drug permeability and toxicity in intestinal segment-specific membrane-based barrier model using Caco-2 and human jejunal and duodenal enteroid-derived cells. Abstract 3217, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025 .
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Topics: modeling , pharmacokinetics
Moyer HL , Vergara L, Stephan C, Sakolish C, Ford LC, Tsai HD, Lin HC, Chiu WA, et al. 2025. Comparative analysis of caco-2 cells and human jejunal and duodenal enteroid-derived cells in gel- and membrane-based barrier models of intestinal permeability. Toxicol Sci 204(2):181-197; doi: 10.1093/toxsci/kfaf011 . PMID: 39886939.
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Topics: modeling
Sakolish C, Moyer HL , Tsai HD, Ford LC, Dickey AN, Bajaj P, Villenave R, Hewitt P, et al. 2025. Comparative analysis of the physiological and transport functions of various sources of renal proximal tubule cells under static and fluidic conditions in PhysioMimix T12 platform. Drug Metab Dispos 53(1):10001; doi: 10.1124/dmd.124.001488 . PMID: 39884810.
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Topics: pharmacokinetics
2024 (4 POSTS)
Lin HC, Sakolish C, Moyer HL , Carmichael PL, Baltazar MT, Ferguson SS, Stanko JP, Hewitt P, et al. 2024. An in vitro-in silico workflow for predicting renal clearance of PFAS. Toxicol Appl Pharmacol 489(Aug):117015; doi: 10.1016/j.taap.2024.117015 . PMID: 38917890.
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Topics: PFAS
Moyer HL , Vergara L, Sakolish C, Lin HC, Hewitt P, Chiu WA, Stephan C, Rusyn I. Comparative analysis of caco-2 cells and human enteroids (jejeunal or duodenal) in gel- and membrane-based barrier models of intestinal permeability. Abstract 461, Microphysiological Systems (MPS) 3rd World Summit, Seattle, WA, June 2024.
Topics: modeling
Moyer H , Kim S, Lam BP, Richardson L, Menon R, Rusyn I, Han A. Fetal response to maternal exposures: Utility of a four-cell human organ-on-chip device to transport and effects of environmental chemicals. Abstract 4236, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. Winner, Reproductive and Developmental Toxicology Specialty Section Poster Award.
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Topics: dose-response , Exposure Assessment , modeling
Lin H, Sakolish C, Moyer HL , Ferguson SS, Stanko JP, Carmichael PL, Hewitt P, Hoffmann S, et al. Predicting renal clearance of PFAS with a human kidney proximal tubule tissue chip and a novel physiologically-based kidney model. Abstract 3508, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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Topics: PFAS
2023 (6 POSTS)
Moyer H , Kim S, Lam BP, Valdiviezo A, Richardson L, Menon R, Rusyn I, Han A. Evaluating mechanistic underpinnings of environmental chemical effects on feto-maternal interface using a human organ-on-chip model. Lonestar Society of Toxicology Meeting, Houston, TX, December 2023.
Topics: modeling
Sakolish C, Moyer HL , Tsai HD, Ford LC, Dickey AN, Wright FA, Han G, Bajaj P, et al. 2023. Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity. Toxicol Sci 196(1):52-70; doi: 10.1093/toxsci/kfad080. PMID: 37555834.
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Topics: modeling
Moyer HL , Kim S, Lam BP, Valdiviezo A, Richardson L, Menon R, Rusyn I, Han A. Evaluating mechanistic underpinnings of environmental chemical effects on feto-maternal interface using a human organ-on-chip model. Texas A&M University Superfund External Advisory Board Meeting, College Station, TX, October 2023.
Topics: modeling
Moyer HL , Kim S, Lam BP, Valdiviezo A, Richardson L, Menon R, Rusyn I, Han A. Evaluating mechanistic underpinnings of environmental chemical effects on feto-maternal interface using a human organ-on-chip model. Texas A&M University Toxicology Annual Retreat, College Station, TX, August 2023.
Topics: modeling
Sakolish C, Moyer H , Fergusson SS, Chiu WA, Rusyn I. Analysis of reproducibility and robustness of PhysioMimix T12, a proximal renal tubule microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs and chemicals. Abstract 3635, Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.
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Topics: pharmacokinetics
Moyer HL , Kim S, Lam BP, Valdiviezo A, Richardson L, Menon R, Rusyn I, Han A. Evaluating mechanistic underpinnings of environmental chemical effects on feto-maternal interface using a human organ-on-chip model. Abstract 3007, Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023. Winner, Perry J. Gehring Best Graduate Student Abstract Award, Risk Assessment Specialty Section.
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Topics: Exposure Assessment , modeling
2022 (9 POSTS)
Moyer H , Vergara, L, Valdiviezo A, Sakolish C, Chiu WA, Stephan C, Rusyn I. Investigation of intestinal permeability in three microphysiological systems. Lonestar Society of Toxicology Meeting, Waco, TX, December 2022.
Topics: modeling
Kato Y, Lim AY, Sakolish C, Valdiviezo A, Moyer HL , Hewitt P, Bajaj P, Han G, Rusyn I. 2022. Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs. Toxicol in Vitro 85(Dec):105464; doi: 10.1016/j.tiv.2022.105464 . PMID: 36057418.
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Topics: pharmacokinetics
Moyer H , Vergara, L, Valdiviezo A, Sakolish C, Chiu WA, Stephan C, Rusyn I. Investigation of intestinal permeability in three microphysiological systems. Texas A&M University Superfund External Advisory Board Meeting, College Station, TX, October 2022.
Topics: modeling
Moyer H , Vergara, L, Valdiviezo A, Sakolish C, Chiu WA, Stephan C, Rusyn I. Investigation of intestinal permeability in three microphysiological systems. Texas A&M University Annual Retreat, College Station, TX, August 2022.
Topics: modeling
Moyer H , Vergara, L, Valdiviezo A, Sakolish C, Chiu WA, Stephan C, Rusyn I. Investigation of intestinal permeability in three microphysiological systems. FutureTox V, Chapel Hill, NC, May 2022.