Publications

Fitch S, van de Ligt J, Payne L, Doepker C, Kleinman R, Handu D, Cohen SM, Anyangwe N, Wikoff D. 2019. Systematic map protocol: A systematic map of the use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS). Open Science Framework.

Wikoff D, Erranguntla N, Lewis J, Foreman J. A fit-for-purpose framework for use of systematic methods in risk assessment. Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Urban J, Wikoff D, Haws L. Three-tiered approach to integrating evidence streams assessing gestational trichloroethylene exposure and congenital heart defects (TCE-CHD). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions, National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Borghoff S, Fitch S, Britt J, Franke K, Wikoff D. Application of the EFSA/ECHA endocrine disruption guidance as a framework for evidence integration in a weight-of-evidence (WoE) analysis for oxybenzone (BP-3). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Urban J, Wikoff D, Suh M, Britt J, Harvey S, Chappell G, Haws L. Comparison of NTP OHAT and US EPA TSCA study quality criteria: Trichloroethylene (TCE) and congenital heart defects (CHDs) as a case study. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Borghoff SJ, Fitch S, Huggett D, Wikoff D. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine disrupting properties of perfluorohexanoic acid (PFHxA). Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Ring CL, Urban J, Wikoff D, Thompson C, Budinsky RA, Haws LC. Application of systematic review and quantitative evidence integration methods to support risk assessment: Characterization of the dose-response relationship between exposure to dioxin-like compounds (DLC) and sperm count. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Wikoff D. Rigor and resources for systematic reviews in toxicology: Case study applications in food safety, consumer product safety, and environmental health risk assessment. Presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Wikoff D, Fitch SE, Payne L, Doepker C, van de Ligt J. 2019. Systematic map: Use of the acceptable daily intake (ADI) values in nutrition research studies that consider the safety of low-calorie sweeteners. Open Science Framework.

Suh M, Wikoff D, Lipworth L, Goodman M, Fitch S, Mittal L, Ring C, Proctor D. 2019. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Crit Rev Toxicol 49(2):140-159; doi: 10.1080/10408444.2019.1578730. PMID: 30896278.

Wikoff DS, Rager JE, Chappell GA, Fitch S, Haws L, Borghoff SJ. 2019. A framework for systematic evaluation and quantitative integration of mechanistic data in assessments of potential human carcinogens. Toxicol Sci 167(2):322-335; doi: 10.1093/toxsci/kfy279. PMID: 30423162.

Wikoff D. Problem formulation: Lessons and tools from practical applications involving systematic review of mechanistic data. Presented at Strategies and Tools for Conducting Systematic Reviews of Mechanistic Data to Support Chemical Assessments, National Academies of Sciences, Engineering, and Medicine, Washington, DC, December 2018.

Urban J, Wikoff D, Haws L, Fitch S, Ring C, Thompson C, Suh M. 2018. Systematic review protocol: Systematic review and meta-regression to characterize the dose-response relationship between exposure to dioxin-like compounds during sensitive windows of development and reduced sperm count. Zenodo. http://doi.org/10.5281/zenodo.1636357.

Tsaioun K, Dirven H, Beck Færden K, Wikoff D, Ram R, Kleinstreuer N, McCormack A, Wright R, Vist GE, Fitch S. 2018. Systematic reviews of the hepatotoxic effects of specified compounds/drugs as observed in humans and experimental animals (rats, mice, dogs and non-human primates). PROSPERO CRD42018112353.

Doepker C, Franke K, Myers E, Goldberger JJ, Lieberman HR, O’Brien C, Peck J, Tenenbein M, Weaver C, Wikoff D. 2018. Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Nutrients 10(10):1536; doi: 10.3390/nu10101536. PMID: 30340340.

Wikoff DS, Thompson C, Rager J, Chappell G, Fitch S, Doepker C. 2018. Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates. Food Chem Toxicol 120(Oct):709-723; doi: 10.1016/j.fct.2018.08.031. PMID: 30134152.

Suh M, Wikoff D, Harvey S, Mittal L, Lipworth L, Goodman M, Goodmanson A, Ring C, Rohr A, Proctor D. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Presented at Joint Annual Meeting of International Society of Exposure Science and International Society for Environmental Epidemiology (ISES-ISEE 2018), Ottawa, Canada, August 2018.

Wikoff D, Goodrum P, Haws L, Budinsky R. Application of quantitative approaches to assess uncertainties in the development of toxicity values: A case study involving the reference dose (RfD) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

Wikoff D. Moving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment. Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

Borghoff S, Wikoff D, Urban JD, Rager JE. A systematic approach to identify plausible mode-of-actions (MOA) for an increased incidence of lung tumors in mice with chronic exposure to 4-methylimidazole (4-MEI). Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.