Publication Topic

Reynolds JI, Johnson BP. 2025. AOP 460: Antagonism of Smoothened receptor leads to orofacial clefting. ALTEX; doi: 10.14573/altex.2407121. Advance online publication August 11, 2025.

Reynolds JI, Yelleti A, Johnson BP. Bridging data gaps in sonic hedgehog signaling: A novel microphysiological model approach. Abstract 3234, Society for Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Reynolds JI, Choi J, Johnson BP. 2024. Crowdsourcing AOP development: Leveraging the thesis literature review to identify knowledge gaps and facilitate research translation. Curr Res Toxicol 7(Aug 8):100191; doi: 10.1016/j.crtox.2024.100191. PMID: 39205829.

Madl AK, Donnell MT, Covell L. Synthetic vitreous fibers (SVFs): Adverse outcome pathways (AOPs) and considerations for new generation new approach methods (NAMs). Poster presentation P863 at Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. In: The Toxicologist 198(S1):492, Abstract 4288.

Reynolds JI, Johnson B. AOP Network: Disruption of sonic hedgehog leading to orofacial clefts. Abstract 3625, Society of Toxicology 63^rd Annual Meeting, Salt Lake City, 2024.

Johnson BP, Reynolds JI. Crowdsourcing AOP development: Leveraging the thesis literature review to identify knowledge gaps and facilitate research translation. Society for Birth Defects Research and Prevention 63rd Annual Meeting, Charleston, SC, 2023.

Goyak KO, Sarang SS, Franzen A, Borghoff SJ, Ryman-Rasumssen JP. 2022. Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats. Crit Rev Toxicol 52(5):345-357; doi: 10.1080/10408444.2022.2082269. PMID: 35862579.

Ponder J, Rajagopal R, Singal M, Baker N, Patlewicz G, Roggen E, Cochrane S, Sullivan K. 2022. “In Litero” screening. Retrospective evaluation of clinical evidence to establish a reference list of human chemical respiratory sensitizers. Front Toxicol 4(Jul 15):916370; doi: 10.3389/ftox.2022.916370. PMID: 35910543.

Wikoff D, Edwards S, Angrish M,… , Borghoff S,… , Fitch S,… , Lea I, Mandel M,… , Urban J, et al. Application of systematic methods to characterize thyroid adverse outcome pathways (AOPs). Presented at 10^th annual meeting of American Society for Cellular and Computational Toxicology (virtual), October 2021.

Palermo CM, Foreman JE, Wikoff DS, Lea I. 2021. Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development. Curr Res Toxicol 2(July 22):254–271; doi: 10.1016/j.crtox.2021.07.002. PMID: 34401750.

de Vries RBM, Angrish M, Browne P, Brozek J, Rooney AA, Wikoff DS, Whaley P, Edwards SW, et al. 2021. Applying evidence-based methods to the development and use of adverse outcome pathways. ALTEX 38(2):336–347; doi: 10.14573/altex.2101211. PMID: 33837437.

Franzen A, Borghoff SJ. An adverse outcome pathway for renal tumors in male rats through chemical induction of aa2u-globuline (a2u) nephropathy (a2u-N). Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.

Svensson F, Zoufir A, Mahmoud S, Afzal AM, Snit S, Giblin KA, Clements PJ,…, Greene N, et al. 2018. Information-derived mechanistic hypotheses for structural cardiotoxicity. Chem Res Toxicol 31(11):1119-1127; doi: 10.1021/acs.chemrestox.8b00159. PMID: 30350600.

Nelms MD, Mellow CL, Enoch SJ, Judson RS, Patlewicz G, Richard AM, Madden JM, Cronin MTD, Edwards SW. 2018. A mechanistic framework for integrating chemical structure and high-throughput screening results to improve toxicity predictions. Comput Toxicol 8(Nov):1-12; doi: 10.1016/j.comtox.2018.08.003. PMID: 36779220.

Clippinger AJ, Allen D, Behrsing H, BéruBé KA, Bolger MA, Casey W, DeLorme M,…, Patlewicz G, et al. 2018. Pathway-based predictive approaches for non-animal assessment of acute inhalation hazard determination. Toxicol in Vitro 52(Oct):131-145; doi: 10.1016/j.tiv.2018.06.009. PMID: 29908304.

Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96(July):30-40; doi: 10.1016/j.yrtph.2018.04.016.

Roberts DW, Patlewicz G. 2018. Non-animal assessment of skin sensitization hazard – Is an integrated testing strategy needed, and if so what should be integrated? J Appl Toxicol 38(1):41-50; doi: 10.1002/jat.3479. PMID: 28543848.

Fitzpatrick J, Patlewicz G. 2017. Application of IATA – A case study in evaluating the global and local performance of a Bayesian network model for skin sensitization. SAR QSAR Environ Res 28(4):297-310; doi: 10.1080/1062936X.2017.1311941. PMID: 28423913.

Patlewicz G, Casati S, Basketter D, Asturiol D, Roberts DW, Lepoittevin J-P, Aschberger K. 2016. Can currently available non-animal methods detect pre and pro haptens relevant for skin sensitization? Regul Toxicol Pharmacol 82(10):147-155;p doi: 10.1016/j.yrtph.2016.08.007. PMID: 27569201.

Worth A, Patlewicz G. 2016. Integrated approaches to testing and assessment. Adv Exp Med Biol 856:317-342; doi: 10.1007/978-3-319-33826-2_13. PMID: 27671729.