Publication Topic

Morgan SJ, Couch J, Guzzie-Peck P, Keller DA, Kemper R, Otieno MA, Schulingkamp RJ, Jones TW. 2017. Regulatory forum opinion piece: Use and utility of animal models of disease for nonclinical safety assessment: A pharmaceutical industry survey. Toxicol Pathol 45(3):372–380, doi: 10.1177/0192623317701004.

Prescott JS, Andrews PA, Baker RW, Bogdanffy MS, Fields FO, Keller DA, Lapadula DM, Mahoney NM, Paul DE, Platz SJ, Reese DM, Stoch SA, DeGeorge JJ. 2017. Evaluation of therapeutics for advanced-stage heart failure and other severely-debilitating or life-threatening diseases. Clin Pharmacol Ther 102(2):219–227, doi: 10.1002/cpt.730.

Ewart L, Fabre K, Chakilam A, Dragan Y, Duignan DB, Eswaraka J, Gan J, Guzzie-Peck P, Otieno M, Jeong CG, Keller DA, de Morais SM, Phillips JA, Proctor W, Sura R, Van Vleet T, Watson D, Will Y, Tagle D, Berridge B. 2017. Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective. Exp Biol Med (Maywood) 242(16):1579–1585, doi: 10.1177/1535370217715441.

Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ. 2017. Current nonclinical testing paradigm enables safe entry to first-in-human clinical trials: The IQ consortium nonclinical to clinical translational database. Toxicol Appl Pharmacol 334:100–109, doi: 10.1016/j.taap.2017.09.006.

Thompson CM, Wolf, JC, McCoy A, Suh M, Proctor DM, Kirman CR, Haws LC, Harris MA. 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101; doi: 10.1177/019262331yy4324.

Wirbisky SE, Weber GJ, Schlotman KE, Sepúlveda MS, Freeman JL. 2016. Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment. Food Chem Toxicol 98:25–33.

LaPlaca SB, Scott GI. Assessing potential endocrine disruption in largemouth bass from a PCB-contaminated reservoir in South Carolina. Poster presentation at the 37th annual meeting of the Society of Environmental Toxicology and Chemistry, North America Chapter, Orlando, FL, November 2016.

Borghoff SJ, Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes.  J Appl Toxicol, DOI 10.1002/jat.3412

Ulrich K. Adversity and risk assessment of respiratory tract findings — A regulatory perspective. Presentation to the 31st Annual Meeting of the British Society of Toxicological Pathology (BSTP) — Association of Inhalation Toxicologists Joint Conference, Alderley Edge, Cheshire, UK, 2016.

Wirbisky SE, Sepúlveda MS, Weber GJ, Jannasch AS, Horzmann KA, Freeman JL. 2016. Embryonic atrazine exposure elicits alterations in genes associated with neuroendocrine function in adult male zebrafish. Toxicol Sci 153:149–164.

Bi P, Yue F, Karki A, Castro B, Wirbisky SE, Wang C, … Kuang, S. 2016. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med 213(10):2019–2037.

Bi P, Yue F, Sato Y, Wirbisky S, Liu W, Shan T, Wen Y, Zhou D, Freeman J, Kuang S. 2016. Stage-specific effects of notch activation during skeletal myogenesis. Elife 5:e17355.

Mackay CE, Vivanco SN, Yeboah G, Vercellone J. 2016. Assessment of dermal hazard from acid burns with fire retardant garments in a full-size simulation of an engulfment flash fire. Burns 42(6):1350–1356; doi: 10.1016/j.burns.2016.04.012.

Haws L. Vapor intrusion – Solid ground or quick sand? Invited Speaker. Presented at the 28th Annual Texas Environmental Superconference, Austin, TX, August 2016.

Haws L. Vapor intrusion – Technical issues. Invited Speaker. Presented at the Semi-Annual South Central Regional Meeting of the Auditing Roundtable, Austin, TX, August 2016.

Klaren WD, Vine D, Vogt S, Robertson LW. Evaluation of the spatial distribution of hepatic metals following PCB126 exposure with x-ray fluorescence microscopy. Society of Toxicology 55th Annual Meeting, New Orleans, LA, 2016.

Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity. Society of Toxicology, Central States Regional Meeting, Iowa City, IA, 2016. Also presented at NIEHS Obesity Grantee Meeting and 25 Years of Endocrine Disruption Workshop, NIH, Bethesda, MD, 2016.

Klaren WD, Iwata Y, Lebakken CS, Grimm FA, Rusyn I. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. College of Veterinary Medicine Graduate Student and Postdoc Research Symposium, Texas A&M University, 2016.

Panko JM, Benson SM, Kreider ML. Meta-analysis of lung cancer risk related to diesel exposure by occupation and evaluation of exposure response. Abstract #2976. Poster at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

Gloekler L, Shay EC, Schmidt N, Haghighat B, Panko JM, Cowan DM, Paustenbach DJ. Flame-retardants in upholstered furnishings: An assessment of health risk and fire-related deaths in the era of California Technical Bulletin (TB-117). Abstract #2669. Poster at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.