Publication Topic

Clewell HJ, Gentry PR, Gearhart JM, Covington TR, Banton MI, Andersen ME. 2001. Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. Toxicol Sci 63:160–172.

Lau C, Mole ML, Copeland FM, Rogers JM, Kavlock RJ, Shuey DL, Cameron AM, Ellis DH, Logsdon TR, Merriman J, Setzer RW. 2001. Toward a biologically-based dose-response model for the developmental toxicity of 5-fluorouracil in the rat: Acquisition of experimental data. Toxicol Sci 59(1):37–48; doi: 10.1093/toxsci/59.1.37.

Setzer RW, Lau C, Mole ML, Copeland FM, Rogers JM, Kavlock RJ. 2001. Toward a biologically-based dose-response model for the developmental toxicity of 5-fluorouracil in the rat: A mathematical construct. Toxicol Sci 59(1):49–58; doi: 10.1093/toxsci/59.1.49.

Rogers JM, Hunter ES III. 2001. Toxicological highlight-Redox redux: A closer look at conceptual low molecular weight thiols. Toxicol Sci 62(1):1–3; doi: 10.1093/toxsci/62.1.1.

Huang Y-S, Held G, Andrews JE, Rogers JM. 2001. 14C-methanol incorporation into DNA and specific proteins of organogenesis-stage mouse embryos in vitro. Reprod Toxicol 15:429–435; doi: 10.1016/s0890-6238(01)00144-7.

Leazer TM, Rogers JM. 2001. Role of the acute phase response and tissue necrosis factor alpha in the developmental toxicity of lipopolysaccharide in the CD-1 mouse. Reprod Toxicol 16(2):173–179; doi: 10.1016/S0890-6238(02)00011-4.

Lea IA, Sivashanmugam P, O’Rand MG. 2001. Zonadhesin: Characterization, localization, and zona pellucida binding. Biol Reprod 65(6):1691–700; doi: 10.1095/biolreprod65.6.1691.

Shipp AM, Gentry PR, Lawrence G, Van Landingham C, Covington T, Clewell HJ, Gribben K, Crump K. 2000. Determination of a site-specific reference dose for methylmercury for fish-eating populations. Toxicol Ind Health 16(9-10):335–438.

Andersen ME, Sarangapani R, Gentry PR, Clewell HJ, Covington TR, Frederick CB. 2000. Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: An example with acrylic acid. Toxicol Sci 57:312–325.

Thompson CM, Capdevila JH, Strobel HW. 2000. Recombinant P450 2D18 metabolism of dopamine and arachidonic acid. J Pharmacol Exper Ther 294(3):1120–1130.

Katona MA, Long TF, Kirman CR, Gargas ML, Rish WR. Derivation of a cancer potency factor and dermal absorption factor for benzo(a)pyrene. Toxicologist 54, Abstract 873. Presented at Society of Toxicology 39th Annual Meeting, Philadelphia, PA, March 2000.

Jankowski-Hennig MA, Clegg MS, Daston GP, Rogers JM, Keen CL. 2000. Zinc-deficient rat embryos have increased caspase 3-like activity and apoptosis. Biochem Biophys Res Commun 271(1):250–256; doi: 10.1006/bbrc.2000.2608.

Lau C, Anderson ME, Crawford-Brown DJ, Kavlock RJ, Kimmel CA, Knudsen TB, Muneoka K, Rogers JM, Setzer RW, Smith G, Tyl R. 2000. Evaluation of biologically based dose-response modeling for developmental toxicity: A workshop report. Regul Toxicol Pharmacol 31(2):190–199; 10.1006/rtph.1999.1360.

Clewell HJ III, Gentry PR, Allen BC, Covington TR, Gearhart JM. 2000. Development of a physiologically-based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment. Environ Health Perspect 108(Suppl 2):283–305.

Gentry R, Clewell H, Covington T, Wilson J. Investigation of the impact of Benchmark and PBPK modeling on the derivation of MRLs. Poster presented at the Society of Toxicology Annual Meeting, Philadelphia, PA, March 2000.

Clewell HJ, Gentry PR, Gearhart JM, Born SL, Lehman-McKeeman LD, Covington TR. Development of a physiologically-based pharmacokinetic (PB-PK) model and human health risk assessment for coumarin.  Poster presented at the Society of Toxicology Annual Meeting, Philadelphia, PA, March 2000.

Choksi NY, Nix WB, Wyrick SD, Booth RG. 2000. A novel phenylaminotetralin (PAT) recognizes histamine H1 receptors and stimulates dopamine synthesis in vivo in rat brain. Brain Research 852(1):151–160; doi: 10.1016/s0006-8993(99)02228-3.

Choksi NY, Nix WB, Wyrick SD, Booth RG. Phenylaminotetralins activate histamine H1 receptors to stimulate dopamine synthesis in vivo in rat brain. Poster presented at the Receptor Chemistry Towards the Third Millennium – 12th Camerino-Noordwijkerhout Symposium, 1999.

Clewell HJ, Gearhart JM, Gentry PR, Covington TR, Van Landingham CB, Crump KS, and Shipp AM. 1999. Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics. Risk Anal 19:541–552.

Rish W, Kirman CR, Hays SM, Gargas ML, Andersen ME, Reitz RH, Guengerich FP, Green T, McConnell EE, Buckpit A, Voytek P, Dugard PH. 1999. Developing a physiologically based pharmacokinetic model to describe methylene chloride kinetics at the subcellular level. Toxicologist 48, Paper No. 671. Presented at Society of Toxicology 38th Annual Meeting, New Orleans, LA, March 1999.